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2way
From Proteopedia
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==Structure of the human DDX6 C-terminal domain in complex with an EDC3- FDF peptide== | ==Structure of the human DDX6 C-terminal domain in complex with an EDC3- FDF peptide== | ||
| - | <StructureSection load='2way' size='340' side='right' caption='[[2way]], [[Resolution|resolution]] 2.30Å' scene=''> | + | <StructureSection load='2way' size='340' side='right'caption='[[2way]], [[Resolution|resolution]] 2.30Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2way]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2way]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WAY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WAY FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2way FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2way OCA], [https://pdbe.org/2way PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2way RCSB], [https://www.ebi.ac.uk/pdbsum/2way PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2way ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/DDX6_HUMAN DDX6_HUMAN] Note=A chromosomal aberration involving DDX6 may be a cause of hematopoietic tumors such as B-cell lymphomas. Translocation t(11;14)(q23;q32). | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DDX6_HUMAN DDX6_HUMAN] In the process of mRNA degradation, may play a role in mRNA decapping. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
| - | *[[Helicase|Helicase]] | + | *[[Helicase 3D structures|Helicase 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Tritschler F]] |
| - | [[Category: | + | [[Category: Weichenrieder O]] |
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Current revision
Structure of the human DDX6 C-terminal domain in complex with an EDC3- FDF peptide
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