Transferrin

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== Structural highlights ==
== Structural highlights ==
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TF contains <scene name='48/480879/Cv/2'>two lobes</scene>: at the N and C termini. The Fe+3 ion is coordinated to several side chains belonging to both N- and C-lobe, carbonate and sulfate ions<ref>PMID:23256035</ref>.
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TF contains <scene name='48/480879/Cv/7'>two lobes</scene>: at the N and C termini. The Fe+3 ion is coordinated to several side chains belonging to both N- and C-lobe, carbonate and sulfate ions<ref>PMID:23256035</ref>.
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*<scene name='48/480879/Cv/5'>N-lobe Fe coordination</scene>.
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*<scene name='48/480879/Cv/8'>N-lobe Fe coordination site</scene>.
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*<scene name='48/480879/Cv/6'>C-lobe Fe coordination</scene>.
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*<scene name='48/480879/Cv/9'>C-lobe Fe coordination site</scene>.
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</StructureSection>
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== 3D Structures of Transferrin ==
== 3D Structures of Transferrin ==
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[[Transferrin 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Transferrin
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**[[3qyt]], [[3v83]], [[4x1b]] – hTF + Fe+3 - human<br />
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**[[4x1d]] – hTF + Yb+3 <br />
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**[[5dyh]], [[5h52]] – hTF + Ti+4 <br />
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**[[4h0w]] – hTF + Fe+3 + Bi+3<br />
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**[[5x5p]], [[5wtd]] – hTF + Fe+3 + Ru+3<br />
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**[[5y6k]] – hTF + Fe+3 + probe<br />
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**[[1suv]] – hTF + TF receptor <br />
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**[[3s9l]], [[3s9m]], [[3s9n]] - hTF (mutant) + TF receptor<br />
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**[[6d03]], [[6d04]], [[6d05]] – TF + TF receptor - ''Pasmodium vivax'' - Cryo EM<br />
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*Transferrin N lobe
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**[[1tfd]] – rTF N terminal - rabbit<br />
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**[[1a8e]], [[1a8f]], [[1b3e]], [[1n84]] - hTF N terminal<br />
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**[[1dtg]], [[1d3k]], [[1d4n]], [[1fqe]], [[1fqf]], [[1jqf]], [[1n7w]], [[1n7x]], [[1oqg]], [[1oqh]], [[2o7u]], [[2o84]], [[3fgs]] - hTF N terminal (mutant)<br />
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**[[1ryo]] - hTF N terminal + oxalate
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*Transferrin C lobe
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**[[3skp]] – hTF C terminal<br />
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*Apo transferrin
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**[[1bp5]], [[1btj]] - hTF N terminal<br />
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**[[2hau]], [[2hav]] – hTF (mutant)<br />
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**[[1jnf]] – rTF <br />
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**[[1h76]] – TF - pig
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*Ovotransferrin
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**[[1ovt]], [[1n04]] – cOTF + Fe+3 - chicken<br />
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**[[2d3i]] – cOTF + Al+3<br />
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**[[1dot]] – dOTF + Fe+3 - duck
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*Ovotransferrin N lobe
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**[[1ovb]], [[1gv8]] – dOTF NII domain <br />
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**[[1gvc]] - dOTF NII domain + nitrilotriacetate<br />
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**[[1nnt]], [[1nft]], [[1iej]] – cOTF N terminal<br />
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*Apo ovotransferrin
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**[[1aov]] – dOTF<br />
 
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**[[1aiv]], [[1ryx]]– cOTF<br />
 
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**[[1tfa]] - cOTF N terminal<br />
 
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**[[1iq7]] - cOTF C terminal<br />
 
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**[[1lfc]] – OTF residues 17-41 – bovine - NMR
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Glycosylated human transferrin with Fe+3 (light red), carbonate and sulfate (PDB code 3qyt).

Drag the structure with the mouse to rotate

References

  1. ↑ de Jong G, van Dijk JP, van Eijk HG. The biology of transferrin. Clin Chim Acta. 1990 Sep;190(1-2):1-46. PMID:2208733
  2. ↑ Liu YS, Xu GY, Cheng DQ, Li YM. Determination of serum carbohydrate-deficient transferrin in the diagnosis of alcoholic liver disease. Hepatobiliary Pancreat Dis Int. 2005 May;4(2):265-8. PMID:15908327
  3. ↑ Yang N, Zhang H, Wang M, Hao Q, Sun H. Iron and bismuth bound human serum transferrin reveals a partially-opened conformation in the N-lobe. Sci Rep. 2012;2:999. doi: 10.1038/srep00999. Epub 2012 Dec 19. PMID:23256035 doi:10.1038/srep00999

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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