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TRNA methyltransferase

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== Structural highlights ==
== Structural highlights ==
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Trm <scene name='55/553109/Cv/3'>active site</scene> is located at the cleft at the subunit interface<ref>PMID:12773376</ref>.
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Trm <scene name='55/553109/Cv/4'>active site</scene> is located at the cleft at the subunit interface<ref>PMID:12773376</ref>. Water molecules are shown as red spheres.
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</StructureSection>
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==3D structures of tRNA methyltransferase==
==3D structures of tRNA methyltransferase==
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[[tRNA methyltransferase 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*'''tRNA guanine 9 N1 methyltransferase'''
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**[[4jwg]] – fyTrm – fission yeast<br />
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**[[4jwf]], [[4jwh]] – fyTrm + SAH <br />
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**[[4jwj]] – yTrm + SAH – yeast<br />
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*'''tRNA guanine 37 N1 methyltransferase'''
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**[[3knu]] – ApTrm – ''Anaplasma phagocytophilum'' <br />
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**[[1oy5]] – AaTrm – ''Aquifex aeolicus'' <br />
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**[[3ief]] – Trm – ''Bartonella henselae'' <br />
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**[[1uaj]] – HiTrm – ''haemophilus influenzae''<br />
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**[[3ky7]] – Trm – ''Staphylococcus aureus''<br />
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**[[3quv]] – Trm – ''Mycobacterium abscessus''<br />
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**[[5hjj]], [[5yac]] – PaTrm – ''Pyrococcus abyssi''<br />
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*Complexes of tRNA guanine 37 N1 methyltransferase
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**[[1uak]], [[4yvg]] – HiTrm + SAM <br />
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**[[1ual]], [[1uam]] – HiTrm + SAH <br />
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**[[3axz]] – HiTrm + adenosine<br />
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**[[4mcb]], [[4mcc]], [[4mcd]] – HiTrm + inhibitor<br />
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**[[4yvh]] – HiTrm + SFG <br />
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**[[4yvi]], [[4yvj]], [[4yvk]] – HiTrm + SFG + tRNA<br />
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**[[5d9f]], [[4ypw]], [[4ypx]], [[4ypy]], [[4ypz]], [[4yq0]], [[4yq1]], [[4yq2]], [[4yq3]], [[4yq4]], [[4yq5]], [[4yq6]], [[4yq7]], [[4yq8]], [[4yq9]], [[4yqa]], [[4yqb]], [[4yqc]], [[4yqg]], [[4yqi]], [[4yqj]], [[4yqk]], [[4yql]], [[4yqn]], [[4yqo]], [[4yqp]], [[4yqq]], [[4yqr]], [[4yqs]], [[4yqt]], [[4yqd]] – HiTrm + SAM competitive<br />
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**[[1p9p]] – EcTrm + SAH – ''Escherichia coli'' <br />
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**[[2yx1]] – MjTrm + SFG – ''Methanocalcococcus jannaschii''<br />
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**[[3ay0]] – MjTrm + adenosine<br />
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**[[4h3y]], [[4h3z]] – Trm + SAH – ''Burkholderia phymatum'' <br />
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**[[4ig6]] – ApTrm + SAH <br />
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**[[4gek]], [[4iwn]] – EcTrm + SAM derivative<br />
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**[[5hr7]] – EcTrm + tRNA-Glu<br />
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**[[5hji]], [[5hjm]] – PaTrm + adenosine derivative<br />
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**[[5hjk]] – PaTrm + SAH <br />
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*'''tRNA guanine 46 N7 methyltransferase'''
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**[[1yzh]] – Trm – ''Streptococcus pneumoniae'' <br />
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**[[2fca]] – Trm – ''Bacillus subtilis'' <br />
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**[[2vdu]], [[2vdv]] – yTrm <br />
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**[[3dxx]] – EcTrm <br />
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*Complexes of tRNA guanine 46 N7 methyltransferase
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**[[3ckk]] – hTrm + SAM - human<br />
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**[[3dxy]] – EcTrm + SAM <br />
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**[[3dxz]] – EcTrm + SAH <br />
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*Trm to O2 of cytidine 32
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**[[4cnd]] – EcTrm (mutant)<br />
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**[[4xbo]] – EcTrm + SAH<br />
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**[[4cne]] – EcTrm (mutant) + SAH<br />
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*'''tRNA cytidine 34 O2 methyltransferase'''
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**[[3e5y]] – BpTrm – ''Burkholderia pseudomalllei'' <br />
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**[[4jak]], [[4kdz]] – EcTrm <br />
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*Complexes of tRNA cytidine 34 O2 methyltransferase
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**[[4kgn]] – BpTrm + SAH <br />
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**[[3n4k]], [[3n4j]] – Trm + SAH – ''Yersinia pestis'' <br />
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**[[1mxi]], [[1im8]] – HiTrm + SAH <br />
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**[[4jal]] – EcTrm + SAH<br />
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*'''tRNA guanine 6 N2 methyltransferase'''
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**[[3tm5]] – PfTrm + SFG – ''Pyrococcvus furiosus''<br />
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**[[3tlj]] – PfTrm + SAH<br />
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**[[3tm4]] – PfTrm + SAM<br />
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*Trm M2G/M22G10
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**[[5e71]] – TkTrm – ''Thermococcvus kodakarensis''<br />
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**[[5e72]] – TkTrm + SAM<br />
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*Trm to N1 of adenine 9
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**[[5a7t]], [[5a7z]] – SaTrm – ''Sulfolobus acidocaldarius''<br />
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**[[4cnf]] – SaTrm (mutant)<br />
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**[[5a7y]] – SaTrm + SAH<br />
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**[[4cng]] – SaTrm (mutant) + SAH<br />
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*'''tRNA adenine 58 N1 methyltransferase'''
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**[[2pwy]] – TtTrm – ''Thermus thermophilus''<br />
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**[[5c0o]], [[5c1i]] – TtTrm (mutant) + SAM<br />
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**[[5eqj]] – yTrm <br />
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**[[5erg]] – yTrm + SAM<br />
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**[[5ccb]], [[5cd1]] – hTrm + SAH + tRNA-Lys<br />
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**[[5ccx]] – hTrm + tRNA-Lys<br />
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*Trm to uracil 34
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**[[4qnx]] – EcTrm <br />
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**[[4qnu]], [[4qnv]] – EcTrm + SAM derivative<br />
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*'''tRNA uracil 54 methyltransferase'''
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**[[3bt7]] – yTrm + RNA<br />
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*Trm9-TRM112
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**[[5cm2]] – Trm – ''Yarrowia lipolytica''<br />
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*Trm dual specificity
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**[[4pl1]], [[4pl2]] – EcTrm (mutant) + SAM<br />
 
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**[[6ems]], [[6emt]] – TkTrm <br />
 
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**[[6emu]] – TkTrm + SAM<br />
 
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**[[6emv]] –TkTrm + SAH<br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Structure of tRNA methyltransferase for N1 of guanine 37 complex with S-adenosylhomocysteine (PDB entry 1uak)

Drag the structure with the mouse to rotate

References

  1. ↑ Swinehart WE, Jackman JE. Diversity in mechanism and function of tRNA methyltransferases. RNA Biol. 2015;12(4):398-411. doi: 10.1080/15476286.2015.1008358. PMID:25626150 doi:http://dx.doi.org/10.1080/15476286.2015.1008358
  2. ↑ Ahn HJ, Kim HW, Yoon HJ, Lee BI, Suh SW, Yang JK. Crystal structure of tRNA(m1G37)methyltransferase: insights into tRNA recognition. EMBO J. 2003 Jun 2;22(11):2593-603. PMID:12773376 doi:10.1093/emboj/cdg269

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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