Tumor necrosis factor ligand superfamily

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== Function ==
== Function ==
'''Tumor necrosis factor ligand superfamily''' (TNFLS) is a family of TNF-like ligands. These cytokines cause wide-ranging long-term cellular activities in cells such as differentiation, proliferation or death<ref>PMID:10891884</ref>, <ref>PMID:8905447</ref>. The TNFLS are ligands for the TNF receptors.
'''Tumor necrosis factor ligand superfamily''' (TNFLS) is a family of TNF-like ligands. These cytokines cause wide-ranging long-term cellular activities in cells such as differentiation, proliferation or death<ref>PMID:10891884</ref>, <ref>PMID:8905447</ref>. The TNFLS are ligands for the TNF receptors.
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==3D structures of tumor necrosis factor ligand superfamily==
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[[Tumor necrosis factor ligand superfamily 3D structures]]
</StructureSection>
</StructureSection>
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==3D structures of tumor necrosis factor ligand superfamily==
 
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
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{{#tree:id=OrganizedByTopic|openlevels=0|
 
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* Tumor necrosis factor ligand superfamily member 2 see [[Tumor necrosis factor]]
 
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* Tumor necrosis factor ligand superfamily member 5 (CD40)
 
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**[[3lkj]], [[1aly]] – hTNFLS5 - human <br />
 
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* Tumor necrosis factor ligand superfamily member 6
 
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**[[5l19]] – hFasL (mutant) <br />
 
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**[[5l36]], [[4msv]] – hFasL + Dcr3 <br />
 
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* Tumor necrosis factor ligand superfamily member 9
 
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**[[6cpr]] – hFasL + Tnf receptor superfanily member 9 <br />
 
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* Tumor necrosis factor ligand superfamily member 10 see [[TRAIL]]
 
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* Tumor necrosis factor ligand superfamily member 11 (RANKL)
 
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**[[5bnq]] – hTNFLS11 + RANK <br />
 
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**[[3urf]] – hTNFLS11 + TNF receptor 11B <br />
 
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**[[1s55]], [[1jtz]] – mTNFLS11 - mouse<br />
 
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**[[4e4d]] – mTNFLS11 + TNF receptor 11B <br />
 
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**[[4giq]], [[3qbq]], [[3me2]] – mTNFLS11 + TNF receptor 11A<br />
 
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* Tumor necrosis factor ligand superfamily member 12
 
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**[[4ht1]] – hTNFLS12 + antibody <br />
 
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* Tumor necrosis factor ligand superfamily member 13 (APRIL)
 
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**[[4zch]], [[1jh5]] – hTNFLS13 <br />
 
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**[[3v56]] – hTNFLS13 + peptide <br />
 
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**[[1oqd]] – hTNFLS13 + BCMA<br />
 
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**[[1oqe]], [[1kd7]] – hTNFLS13 + BAFF<br />
 
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**[[1u5x]], [[1u5y]], [[1u5z]] – mTNFLS13 <br />
 
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**[[1xu1]] – mTNFLS13 + TACI <br />
 
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**[[1xu2]] – mTNFLS13 + BCMA<br />
 
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**[[3k48]] – mTNFLS13 extracellular domain + peptide<BR />
 
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* Tumor necrosis factor ligand superfamily member 14
 
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**[[4en0]] – hTNFLS14 <br />
 
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**[[4kg8]] – hTNFLS14 (mutant) <br />
 
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**[[4kgg]], [[4kgq]], [[4j6g]] – hTNFLS14 (mutant) + Dcr3 <br />
 
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* Tumor necrosis factor ligand superfamily member 15 (TL1A)
 
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**[[3mi8]], [[3k51]] – hTNFLS15 + Dcr3 <br />
 
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**[[2rjk]], [[2rjl]] – hTNFLS15 (mutant) <br />
 
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**[[2o0o]], [[2re9]], [[2qe3]] – hTNFLS15 <br />
 
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* Tumor necrosis factor ligand superfamily member 18 (GITRL)
 
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**[[4g4f]] – TNFLS18 - bushbaby <br />
 
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**[[4db5]] – TNFLS18 - rabbit <br />
 
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**[[4e4s]] – TNFLS18 - pika <br />
 
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**[[2qdn]], [[3b9i]], [[2q8o]] – mTNFLS18 <br />
 
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**[[3b93]], [[3b94]], [[2r32]], [[2q1m]] – hTNFLS18 <br />
 
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**[[2r30]] – hTNFLS18 (mutant) <br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Tumor necrosis factor ligand superfamily member 10 (grey, green, pink) complex with TNF receptor TRAIL (wheat, magenta, cyan), Zn+2 (grey) and Cl- (green) ions (PDB code 4e4d)

Drag the structure with the mouse to rotate

References

  1. ↑ Idriss HT, Naismith JH. TNF alpha and the TNF receptor superfamily: structure-function relationship(s). Microsc Res Tech. 2000 Aug 1;50(3):184-95. PMID:10891884 doi:<184::AID-JEMT2>3.0.CO;2-H http://dx.doi.org/10.1002/1097-0029(20000801)50:3<184::AID-JEMT2>3.0.CO;2-H
  2. ↑ Gruss HJ. Molecular, structural, and biological characteristics of the tumor necrosis factor ligand superfamily. Int J Clin Lab Res. 1996;26(3):143-59. PMID:8905447

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Michal Harel

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