Tyrosine phosphatase

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Human tyrosine phosphatase 1B catalytic domain (grey) complex with EGFR peptide (in green), VO4, glycerol, Tris, 2-amino-2-hydroxymethyl-1,3-diol, 3i7z

Drag the structure with the mouse to rotate

1 Function
2 Disease
3 3D Structures of tyrosine phosphatase
4 References

Function

Tyrosine phosphatase or Protein tyrosine phosphatase (PTP) is an enzyme which removes phosphate from phosphorylated tyrosine residues. It is a key regulatory component of signal transduction pathways^[1]. PTPs are divided to 4 subfamilies.

PTP class I contains receptor PTPs (RPTP) and dual-specificity PTP which removes phosphate from Ser/Thr and tyrosine. Human PTP PRL is found in regenerating liver.
PTP class II are low molecular weight PTP (LMW-PTP) which dephosphorylate a number of growth factors and modulate their signalling processes^[2].
PTP class III contains CDC25 which removes phosphate from Thr and tyrosine. PTP containing SH2 domains are called PTP SHP.
Yersinia PTP see Yersinia YopH.
Non-receptor type PTPs are coded by the PTPN genes.
T-cell PTP is a non-receptor type PTP expressed in hematopoietic tissues influencing most cells in the immune system^[3].

For details of PTP complex with inhibitor see Student Projects for UMass Chemistry 423 Spring 2012-9.

Disease

PTP mutations are involved in cancers^[4].

3D Structures of tyrosine phosphatase

Tyrosine phosphatase 3D structures

References

↑ Paul S, Lombroso PJ. Receptor and nonreceptor protein tyrosine phosphatases in the nervous system. Cell Mol Life Sci. 2003 Nov;60(11):2465-82. PMID:14625689 doi:http://dx.doi.org/10.1007/s00018-003-3123-7
↑ Caselli A, Paoli P, Santi A, Mugnaioni C, Toti A, Camici G, Cirri P. Low molecular weight protein tyrosine phosphatase: Multifaceted functions of an evolutionarily conserved enzyme. Biochim Biophys Acta. 2016 Oct;1864(10):1339-55. doi:, 10.1016/j.bbapap.2016.07.001. Epub 2016 Jul 13. PMID:27421795 doi:http://dx.doi.org/10.1016/j.bbapap.2016.07.001
↑ Doody KM, Bourdeau A, Tremblay ML. T-cell protein tyrosine phosphatase is a key regulator in immune cell signaling: lessons from the knockout mouse model and implications in human disease. Immunol Rev. 2009 Mar;228(1):325-41. PMID:19290937 doi:10.1111/j.1600-065X.2008.00743.x
↑ Ostman A, Hellberg C, Bohmer FD. Protein-tyrosine phosphatases and cancer. Nat Rev Cancer. 2006 Apr;6(4):307-20. PMID:16557282 doi:http://dx.doi.org/10.1038/nrc1837

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Tyrosine phosphatase

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Function

Disease

3D Structures of tyrosine phosphatase

References

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@@ Line 1: / Line 1: @@
 <StructureSection load='3i7z' size='340' side='right' caption='Human tyrosine phosphatase 1B catalytic domain (grey) complex with EGFR peptide (in green), VO4, glycerol, Tris, 2-amino-2-hydroxymethyl-1,3-diol, [[3i7z]]' scene='' >
-'''Tyrosine phosphatase''' (PTP) is an enzyme which removes phosphate from phosphorylated tyrosine residues.  It is a key regulatory component of signal transduction pathways<ref>PMID:14625689</ref>.  PTPs are divided to 4 subfamilies.  '''PTP class I''' contains receptor PTPs (RPTP) and dual-specificity PTP which removes phosphate from Ser/Thr and tyrosine.   '''PTP class II''' are low moleculat weight PTP which dephosphorylate a number of growth factors and modulate their signalling processes<ref>PMID:27421795</ref>.  '''PTP class III''' contains CDC25 which removes phosphate from Thr and tyrosine.  PTP containing SH2 domains are called PTP SHP.<br />For details on ''Yersinia'' PTP see [[Yersinia YopH]].<br />For details of PTP complex with inhibitor see [[Student Projects for UMass Chemistry 423 Spring 2012-9]].
+__TOC__
+==Function==
+'''Tyrosine phosphatase''' or '''Protein tyrosine phosphatase''' (PTP) is an enzyme which removes phosphate from phosphorylated tyrosine residues.  It is a key regulatory component of signal transduction pathways<ref>PMID:14625689</ref>.  PTPs are divided to 4 subfamilies.
+*'''PTP class I''' contains receptor PTPs (RPTP) and dual-specificity PTP which removes phosphate from Ser/Thr and tyrosine.   Human '''PTP PRL''' is found in regenerating liver.
+*'''PTP class II''' are low molecular weight PTP ('''LMW-PTP''') which dephosphorylate a number of growth factors and modulate their signalling processes<ref>PMID:27421795</ref>.
+*'''PTP class III''' contains CDC25 which removes phosphate from Thr and tyrosine.  PTP containing SH2 domains are called PTP SHP.
+*'''Yersinia PTP''' see [[Yersinia YopH]].<br />
+*'''Non-receptor type PTPs''' are coded by the PTPN genes. <br />
+*'''T-cell PTP''' is a non-receptor type PTP expressed in hematopoietic tissues influencing most cells in the immune system<ref>PMID:19290937</ref>.
+For details of PTP complex with inhibitor see [[Student Projects for UMass Chemistry 423 Spring 2012-9]].
 == Disease ==
 PTP mutations are involved in cancers<ref>PMID:16557282</ref>.
-</StructureSection>
 == 3D Structures of tyrosine phosphatase ==
+[[Tyrosine phosphatase 3D structures]]
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*'''Class I'''
-*'''Non-receptor type tyrosine phosphatase'''
-**[[1a5y]], [[2hnp]], [[2hnq]], [[1oem]], [[1oeo]], [[1oes]], [[1oet]], [[1oeu]], [[1oev]], [[1sug]], [[2cm2]], [[2cm3]], [[3eu0]], [[3i80]], [[3a5j]], [[1bzc]] - hPTP-b catalytic domain – human<br />
-**[[1gfy]], [[1i57]], [[1pa1]], [[2f6f]], [[3a5k]], [[3zv2]], [[3qkp]], [[3qkq]] - hPTP-b catalytic domain (mutant) <br />
-**[[1wch]] – hPTP-e<br />
-**[[3pdz]] - hPTP-e PDZ2 domain – NMR<BR />
-**[[1gm1]] - mPTP-BL PDZ2 domain – mouse – NMR<BR />
-**[[1ozi]] - mPTP-BL PDZ2 domain (mutant) – NMR<BR />
-**[[3rgo]] – mPTP-1<br />
-**[[2yz1]] – mPTP SHPS-1 catalytic domain<br />
-**[[5k9v]] – hPTPN1<br />
-**[[4qah]], [[4qap]], [[4qbe]], [[4qbw]], [[5kaa]], [[5ka8]], [[5ka4]], [[5ka2]], [[5ka1]], [[5ka0]] – hPTPN1 (mutant)<br />
-**[[6b8e]], [[6b8t]], [[6b8x]], [[6b90]] – hPTPN1B catalytic domain<br />
-**[[6bai]] – hPTPN1B catalytic domain (mutant)<br />
-**[[2b49]] – hPTPN3 catalytic domain<br />
-**[[4qun]] – hPTPN3 catalytic domain (mutant) <br />
-**[[2i75]] – hPTPN4<br />
-**[[2cs5]] – hPTPN4 PDZ domain – NMR<BR />
-**[[2vph]] - hPTPN4 PDZ domain<br />
-**[[2bij]] – hPTPN5 catalytic domain<br />
-**[[2bv5]] - hPTPN5 catalytic domain (mutant) <br />
-**[[4hjp]], [[1gwz]], [[2b3o]] – hPTPN6 catalytic domain <br />
-**[[4gry]], [[4grz]], [[4hjq]], [[3ps5]] – hPTPN6 catalytic domain (mutant)<br />
-**[[2dn7]] - hPTPN6 FN3 #6 domain - NMR<br />
-**[[2dju]], [[2edy]] - hPTPN6 FN3 domain - NMR<br />
-**[[1x6c]] - hPTP hPTPN6 SH2 domain – NMR<BR />
-**[[2a3k]], [[1zc0]] – hPTPN7 catalytic domain<br />
-**[[2gp0]], [[2hvl]], [[2qdc]], [[2qdm]], [[2qdp]], [[2qds]], [[2qdt]], [[2qdu]], [[3o4s]], [[3o4t]], [[3o4u]] – hPTPN7 catalytic domain (mutant) <br />
-**[[2pa5]] – hPTPN9 catalytic domain<br />
-**[[3b7o]], [[3zm0]], [[3zm1]], [[3zm2]], [[3zm3]] - hPTPN11 catalytic domain<br />
-**[[4dgp]] - hPTPN11 SH2+catalytic domains<br />
-**[[4dgx]], [[4gwf]], [[4h1o]], [[4h34]], [[4nwf]], [[4nwg]], [[4ohd]], [[4ohe]], [[4ohh]], [[4ohi]], [[4ohl]] - hPTPN11 SH2+catalytic domains (mutant)<br />
-**[[5j8r]], [[5i6v]], [[5ibm]], [[5ibs]], [[6atd]], [[2shp]] - hPTPN11 catalytic domain (mutant)<br />
-**[[5hde]] - hPTPN12 catalytic domain <br />
-**[[5glj]] - hPTPN13 PDZ1 domain <br />
-**[[3lnx]] – hPTPN13 PDZ2 domain<br />
-**[[2m0z]] - hPTPN13 PDZ2 domain (mutant) – NMR<br />
-**[[2bzl]] – hPTPN14 catalytic domain<br />
-**[[2oc3]] – hPTPN18<br />
-**[[2p6x]], [[2qcj]], [[3h2x]] – hPTPN22 catalytic domain<br />
-**[[5cru]], [[5mjz]], [[3rau]] – hRPTP23 domain Bro residues 1-361<br />
-**[[5lm2]] – hRPTP23 residues 362-713<br />
-**[[1xm2]], [[1rxd]] – hPTP PRL-1<br />
-**[[1r6h]], [[1v3a]], [[2mbc]] – hPTP PRL-3 – NMR<BR />
-**[[1rxd]] - hPTP IVA-1<br />
-**[[1zck]], [[1x24]] – rPTP 4A1 – rat<br />
-**[[3i36]] – rPTP-η catalytic domain<br />
-**[[1c0e]] – bPTP (mutant) – bovine<br />
-**[[1d1p]], [[2j16]], [[6byf]] – yPTP - yeast<br />
-**[[2j17]] - yPTP (mutant)<br />
-**[[5xw4]] – yPTPN CDC14 <br />
-**[[1g4w]] – StPTP – ''Salmonella typhimurium''<br />
-**[[2i6i]], [[3ro1]] – SsPTP – ''Sulfolobus solfataricus''<br />
-**[[2pi7]] – cPTP CRYP-2 catalytic domain <br />
-**[[2z72]], [[1v73]], [[2zbm]] – PTP residues 22-361 – ''Shewanella''<br />
-**[[3js5]], [[3jvi]] – EhPTP – ''Entamoeba histolytica''<br />
-**[[2wjd]], [[2wje]], [[2wjf]] – PTP – ''Streptococcus pneumonia''<br />
-**[[5z59]], [[5z5a]] – TkPTP – ''Thermococcus kodakarensis'' <br />
-**[[5z5b]] - TkPTP (mutant)<br />
-**[[3qy6]], [[3qy7]], [[3qy8]] – BsPTP – ''Bacillus subtilis''
-*Non-receptor type PTP complex with peptide
-**[[3zmp]], [[3zmq]], [[4zrt]] – hPTPN1 catalytic domain + peptide<br />
-**[[3i7z]] - hPTP1B catalytic domain + peptide<br />
-**[[1ptt]], [[1ptu]], [[1g1f]], [[1g1g]], [[1g1h]], [[1een]], [[1eeo ]] - hPTP1B catalytic domain (mutant) + peptide<br />
-**[[1bzh]] - hPTP1B catalytic domain + fluoromalonyl tyrosine peptide<br />
-**[[1bzj]] - hPTP1B catalytic domain + phosphotyrosine mimetic<br />
-**[[4qum]], [[4rh5]], [[4rh9]], [[4rhg]], [[4s0g]] – hPTPN3 catalytic domain (mutant) + peptide<br />
-**[[3nfk]], [[3nfl]], [[5eyz]], [[5ez0]] - hPTPN4 PDZ domain + peptide<br />
-**[[2yu7]], [[2rmx]] – hPTPN6 SH2 domain + peptide – NMR<BR />
-**[[4gs0]] – hPTPN6 catalytic domain + peptide<br />
-**[[3d42]], [[3d44]] – hPTPN7 catalytic domain (mutant) + peptide<br />
-**[[4icz]] – hPTPN9 catalytic domain + peptide<br />
-**[[3tl0]], [[3tkz]],[[5df6]], [[4qsy]],[[5x94]], [[5x7b]] – hPTPN11 SH2 domain + peptide<br />
-**[[5o2p]] – hPTPN12 SH3 domain/peptide<br />
-**[[3lny]] - hPTPN13 PDZ2 domain + peptide<br />
-**[[4gfu]], [[4gfv]] - hPTPN18 residues 6-300 + peptide<br />
-**[[4nnd]] - hPTPN18 residues 6-300 (mutant) + ERBB-2<br />
-**[[3brh]], [[3olr]] - hPTPN22 catalytic domain + peptide<br />
-**[[3omh]] - hPTPN22 catalytic domain (mutant) + peptide<br />
-**[[5crv]], [[5mk3]], [[5mk2]], [[5mk1]], [[5mk0]], [[5mjy]]  – hRPTP23 domain Bro + STAM2 peptide<br />
-**[[5lm2]] – hRPTP23 residues 362-713 + UBAP-1 peptide<br />
-**[[3rz2]] - rPTP 4A1 + peptide<br />
-**[[1fpr]] - hPTP SHP-1 catalytic domain + peptide<br />
-**[[1aya]], [[1ayb]], [[1ayc]], [[1ayd]] – mPTP Syp N terminal SH2 domain + peptide<br />
-**[[1vj6]] – mPTP PDZ2 domain + APC C terminal – NMR<br />
-**[[2dxp]], [[2i6o]] – SsPTP (mutant) + peptide<br />
-**[[5xw5]] – yPTPN CDC14 + SWI6 peptide<br />
-*Non-receptor type PTP complex with small molecule
-**[[1ptv]], [[1pty]] - hPTP1B catalytic domain (mutant) + phosphotyrosine<br />
-**[[1aax]] - hPTP1B catalytic domain (mutant) + bis-phosphophenyl methane<br />
-**[[1ecv]], [[1c83]], [[1c84]], [[1c85]], [[1c86]], [[1c87]], [[1c88]], [[1g7f]], [[1g7g]], [[1jf7]], [[1l8g]], [[1kak]], [[1kav]], [[1lqf]], [[1nl9]], [[1nny]], [[1no6]], [[1nz7]], [[1ony]], [[1onz]], [[1ph0]], [[1pxh]], [[1pyn]], [[1q1m]], [[1q6j]], [[1q6m]], [[1q6n]], [[1q6p]], [[1q6s]], [[1q6t]], [[1qxk]], [[1t48]], [[1t49]], [[1t4j]], [[1xbo]], [[1wax]], [[2bgd]], [[2bge]], [[2azr]], [[2b07]], [[2f6t]], [[2f6v]], [[2f6w]], [[2f6y]], [[2f6z]], [[2f70]], [[2f71]], [[2fjn]], [[2cm7]], [[2cm8]], [[2cma]], [[2cmb]], [[2cmc]], [[2h4g]], [[2h4k]], [[2hb1]], [[2cne]], [[2cnf]], [[2cng]], [[2cnh]], [[2cni]], [[2nt7]], [[2nta]], [[2veu]], [[2vev]], [[2vew]], [[2vex]], [[2vey]], [[2qbp]], [[2qbq]], [[2qbr]], [[2qbs]], [[3cwe]], [[3d9c]], [[2zmm]], [[2zn7]], [[3eax]], [[3eb1]], [[3sme]], [[4i8n]], [[4y14]], [[6bmr]], [[6bmv]], [[6bmx]], [[6bmu]], [[6bmw]], [[6bmy]], [[5t19]], [[5k9w]], [[6b8z]] - hPTP1B catalytic domain + inhibitor<br />
-**[[5kad]], [[5kac]], [[5kab]], [[5ka9]], [[5ka7]], [[5ka3]], [[6b95]], [[1nwl]], [[1nwe]], [[2fjm]], [[6bn5]] – hPTPN1B (mutant) + inhibitor<br />
-**[[4bjo]] – hPTP1 catalytic domain + NO3<br />
-**[[4ri4]], [[4ri5]] – hPTPN3 catalytic domain (mutant) + VO4<br />
-**[[6h8r]] – hPTPN5 + inhibitor<br />
-**[[2cjz]] - hPTPN5 catalytic domain (mutant) + phosphotyrosine<br />
-**[[4ge2]], [[4ge5]], [[4ge6]] – hPTP9 catalytic domain + inhibitor<br />
-**[[3o5x]], [[4pvg]], [[5ehp]], [[5ehr]], [[4rdd]] – hPTPN11 catalytic domain + inhibitor<br />
-**[[3mow]] - hPTPN11 catalytic domain + tautomycetin analog<br />
-**[[2m10]] - hPTPN13 PDZ2 domain (mutant) + azobenzene derivative – NMR<br />
-**[[2qct]], [[4j51]] – hPTPN22 catalytic domain + inhibitor<br />
-**[[5h08]] – hPTP ζ D1 domain + inhibitor<br />
-**[[5bx1]] – hPTP PRL-1 + inhibitor<br />
-**[[1zcl]] - rPTP 4A1 (mutant) + sulfate<br />
-**[[1dg9]] – bPTP + HEPES<br />
-**[[1d2a]] – yPTP + adenine <br />
-**[[1d1q]] – yPTP (mutant) + PNPP<br />
-**[[2i6p]] - SsPTP (mutant) + PNPP<br />
-**[[2i6j]] – SsPTP + phosphate<br />
-**[[2i6m]] – SsPTP + WO4<BR />
-**[[3ido]] – EhPTP + HEPES<br />
-**[[3rgq]] – mPTP-1 + Pi(5)P<br />
-**[[6h8s]] – mPTPN5 + inhibitor<br />
-*Non-receptor type PTP complex with protein
-**[[2b4s]] - hPTP1B catalytic domain + insulin receptor<br />
-**[[2gph]] - hPTPN7 catalytic domain (mutant) + MAPK2<br />
-**[[1g4u]] – StPTP + RAS-related C3 botulinum toxin substrate <br />
-**[[1jyo]] – StPTP + secretion chaperone SICP<br />
-**[[4je4]], [[4jeg]] – hPTPN11 catalytic domain + monobody<br />
-**[[5lxq]] – mPTP  + CNNM2<br />
-**[[5k25]], [[5k24]], [[5k23]] – hPTP PRL-2 + CNNM3<br />
-**[[5k22]] – hPTP PRL-2 (mutant) + CNNM3<br />
-**[[5tsr]] – hPTP PRL-3 (mutant) + CNNM3<br />
-**[[5mmz]] – mPTP 4A1 + CNNM2<br />
-**[[4zj7]] – yPTPN CDC14 C terminal + importin<br />
-*'''Yersinia tyrosine phosphatase Yop'''
-**[[1yts]], [[4yaa]], [[4z6b]], [[4zi4]], [[4zn5]] - YePTP catalytic domain (mutant) – ''Yersinia enterocolitica''<br />
-**[[1xxp]], [[1xxv]] - YePTP catalytic domain (mutant) + peptide<br />
-**[[2i42]] – YePTP (mutant) + VO4<br />
-**[[1ypt]], [[1ytw]] – YePTP catalytic domain + WO4<br />
-**[[1ytn]] - YePTP catalytic domain + NO3<br />
-**[[1lyv]] - YePTP catalytic domain (mutant) + phosphate<br />
-**[[1pa9]], [[3bm8]] - YePTP catalytic domain (mutant) + inhibitor<br />
-**[[3u96]] - YePTP catalytic domain (mutant) + PNCS<br />
-**[[1huf]] – YpPTP - ''Yersinia pestis''<br />
-**[[1qz0]] - YpPTP catalytic domain + peptide<br />
-**[[2y2f]] - YpPTP catalytic domain + inhibitor<br />
-**[[1k46]] - YpPTP N terminal domain<br />
-**[[1m0v]] - YpPTP N terminal domain + peptide – NMR<br />
-**[[4gf3]] – YpPTP + Yop targeting protein<br />
-*'''Receptor-type tyrosine phosphatase'''
-**[[1yfo]], [[2i1y]] – mRPTP-α catalytic domain<br />
-**[[1p15]] - mRPTP-α D2 domain<br />
-**[[3pxh]] - mRPTP Ig domains<br />
-**[[1jln]], [[2a8b]] - mRPTP-R catalytic domain<br />
-**[[3sr9]] - mRPTP-σ residues 1326 – 1901<br />
-**[[2nv5]] – RPRP - rat<br />
-**[[2yd4]] - cRPTP-σ Ig1-2 domain – chicken<br />
-**[[2yd1]], [[2yd2]], [[3pxj]] – DmRPTP Ig1-2 domain – ''Drosophila melanogaster''<br />
-**[[3s3e]] – DmRPTP-10D catalytic domain<br />
-*'''Human receptor-type tyrosine phosphatase'''
-**[[2ahs]] – hRPTP-β<br />
-**[[2i3r]], [[2i5x]] - hRPTP-β catalytic domain<br />
-**[[2hc1]], [[2hc2]] - hRPTP-β catalytic domain (mutant) <br />
-**[[2h4v]], [[2pbn]] – hRPTP-γ domain 1<br />
-**[[3qcn]] - hRPTP-γ domain 1 (mutant) <br />
-**[[2nlk]] - hRPTP-γ catalytic domain<br />
-**[[3jxg]], [[3jxh]] - mRPTP-γ CA-like domain<br />
-**[[3jxh]] - hRPTP-γ CA-like domain<br />
-**[[5fmv]] - hRPTP-γ domain D1-D4<br />
-**[[5fn6]] - hRPTP-γ domain D1-D3<br />
-**[[5fn7]] - hRPTP-γ domain D1-D2<br />
-**[[5fn8]] - rRPTP-γ domain D3-D4<br />
-**[[1x5z]] - hRPTP-δ fibronectin type-III domain – NMR<BR />
-**[[4yfe]] - hRPTP-δ FN1-FN2 domain<br />
-**[[4yfg]] - hRPTP-δ Ig1-FN1 domain<br />
-**[[2dlh]] - hRPTP-δ FN3 domain – NMR<BR />
-**[[2yd6]], [[2yd7]] - hRPTP-δ Ig1-2 domain<br />
-**[[2jjd]] - hRPTP-ε residues 107-697<br />
-**[[2c7s]] - hRPTP-κ residues 865-1154<br />
-**[[1rpm]] - hRPTP-μ catalytic domain<br />
-**[[2c9a]] - hRPTP-μ MAM-IG module<br />
-**[[2v5y]] - hRPTP-μ extracellular region<br />
-**[[2g59]], [[2gjt]] - hRPTP-ο catalytic domain<br />
-**[[2cfv]] – hRPTP-η residues 1019-1311<br />
-**[[2nz6]] - hRPTP-η residues 1019-1311 (mutant) <br />
-**[[2dle]] - hRPTP-η FN3 domain – NMR<BR />
-**[[2qep]] – hRPTP-ν2 D1 domain<br />
-**[[4hti]], [[4htj]] – hRPTP-ν2 membrane proximal ectodomain<br />
-**[[2ooq]] – hRPTP-ρ<br />
-**[[2fh7]], [[4bpc]] - hRPTP-σ catalytic domain (mutant) <br />
-**[[2yd9]] - hRPTP-σ Ig1-3 domain (mutant) <br />
-**[[2yd3]], [[2yd5]] - hRPTP-σ Ig1-2 domain<br />
-**[[4pbx]] - hRPTP-σ residues 30-588<br />
-**[[3jxf]] - hRPTP-ζ CA-like domain<br />
-**[[5awx]] - hRPTP-ζ D1 domain<br />
-**[[2qt7]], [[3n01]], [[3n4w]], [[3ng8]], [[3np5]] – hRPTP IA-2<br />
-**[[4n5u]] - hRPTP-F fibronectin type-III domain<br />
-**[[2edx]] - hRPTP-F fibronectin type-III domain – NMR<BR />
-*Receptor type tyrosine phosphatase complexes
-**[[3s3f]] - DmRPTP-10D catalytic domain + VO4<BR />
-**[[3s3h]] - DmRPTP-10D catalytic domain + peptide<br />
-**[[3s3k]] - DmRPTP-10D catalytic domain + inhibitor<br />
-**[[2h02]], [[2h04]], [[2i3u]], [[2i4e]], [[2i4g]], [[2i4h]] - hRPTP-β catalytic domain + inhibitor<br />
-**[[2h03]] - hRPTP-β catalytic domain (mutant) + inhibitor<br />
-**[[2hy3]], [[3qcb]], [[3qcc]], [[3qcd]]  - hRPTP-γ domain 1 + VO4<BR />
-**[[3qce]], [[3qcf]], [[3qcg]], [[3qch]], [[3qci]], [[3qcj]], [[3qck]] - hRPTP-γ domain 1 + inhibitor<br />
-**[[3qcl]], [[3qcm]] - hRPTP-γ domain 1 (mutant) + inhibitor<br />
-**[[5e5r]] - hRPTP-γ domain CA + contactin 3<br />
-**[[5e5u]] - mRPTP-γ domain CA + contactin 6<br />
-**[[3kld]] - mRPTP-γ CA-like domain + contactin 4<br />
-**[[4rca]], [[4y61]] - hRPTP-δ + SLITRK1<br />
-**[[5y32]], [[4yfd]], [[4yh7]] - hRPTP-δ + IL1RAPL1<br />
-**[[2yd8]] - hRPTP-σ Ig1-2 domain + sucrose octasulfate<br />
-**[[3s97]] - hRPTP-ζ CA-like domain + congtactin Ig domains<br />
-**[[1ygr]] – hRPTP CD45 cytoplasmic domain (mutant) + T-cell receptor peptide<br />
-*'''Dual-specificity tyrosine phosphatase'''
-**[[1t3k]] – DUSP (mutant) – ''Arabidopsis thaliana''<br />
-**[[6apx]] – hDUSP-1/MBP + monobody<br />
-**[[2g6z]] – hDUSP-5<br />
-**[[4y2e]] – hDUSP-7 (mutant)<br />
-**[[3lj8]] – hDUSP-9<br />
-**[[4jnb]], [[4ki9]] – hDUSP-12 catalytic domain (mutant)<br />
-**[[2wgp]] – hDUSP-14 residues 2-191<br />
-**[[4yr8]] – hDUSP-16 + MAPK8<br />
-**[[4d3p]], [[4d3q]], [[4d3r]] – hDUSP-19 (mutant)<br />
-**[[4woh]] – hDUSP-22 (mutant) + nitrophenolphosphate<br />
-**[[5gtj]] – hDUSP-26<br />
-*'''Class II'''
-*'''Low molecular weight tyrosine phosphatase (LMW-PTP)'''
-**[[1p8a]] – LMW-PTP (mutant) – ''Tritrichomonas foetus'' – NMR<BR />
-**[[2cwd]] – LMW-PTP – ''Thermus thermophilus''<br />
-**[[5got]] – LMW-PTP – ''Streptococcus pyogenes''<br />
-**[[1phr]] - bLMW-PTP<br />
-**[[1xww]], [[4z99]] - hLMW-PTP <br />
-**[[1u2p]], [[2luo]] – MtLMW-PTP – ''Mycobacterium tuberculosis''<br />
-**[[2oz5]] – MtLMW-PTP + inhibitor<br />
-**[[2fek]] – LMW-PTP – ''Escherichia coli''<br />
-**[[4eti]], [[4etm]], [[4kk3]] – BsLMW-PTP<br />
-**[[4etn]], [[4kk4]] – BsLMW-PTP (mutant)<br />
-*LMW-PTP complex
-**[[5kqg]], [[5kql]], [[5kqm]], [[5kqp]] – hLMW-PTP + inhibitor<br />
-**[[4z9a]] – hLMW-PTP + phenylmethanesulfonic acid<br />
-**[[4z9b]] – hLMW-PTP + benzylphosphonic acid<br />
-**[[1z12]] - bLMW-PTP + VO4<br />
-**[[1z13]] - bPTP + MoO4<br />
-**[[5jnw]] – bLMW-PTP + inhibitor <br />
-**[[3rof]] – LMW-PTP-A + peptide – ''Staphylococcus aureus''<br />
-**[[1u2q]] – MtLMW-PTP + glycerol<br />
-**[[2oz5]] – MtLMW-PTP + inhibitor<br />
-*'''Class III or M-phase inducer phosphatase 2'''
-*'''CDC25'''
-**[[1c25]] – hCDC25A catalytic domain (mutant) <br />
-**[[1qb0]], [[1cwr]], [[1ym9]], [[1ymd]], [[1ymk]], [[1yml]], [[1ys0]], [[2uzq]] - hCDC25B catalytic domain<br />
-**[[2a2k]], [[2ifd]], [[2ifv]] - hCDC25B catalytic domain (mutant) <br />
-**[[4wh7]] - hCDC25B catalytic domain (mutant) + ligand<br />
-**[[4wh9]] - hCDC25B catalytic domain (mutant) + inhibitor<br />
-**[[1cwr]], [[1cws]] - hCDC25B catalytic domain + WO4<BR />
-**[[1cwt]] - hCDC25B catalytic domain + Methyl-Hg<br />
-**[[3op3]] – hCDC25C residues 270-462
-*'''Class IV'''
-**[[4tvv]] – PTP – ''Legionella pneumophila''<br />
-*'''T-cell tyrosine phosphatase'''
-**[[1l8k]] – hTC-PTP
-*'''Other tyrosine phosphatases'''
-**[[4az1]] – PTP – ''Trypanosoma cruzi''<br />
-**[[4r0s]] – PaPTP – ''Pseudomonas aeruginosa''<br />
-**[[4r0t]] – PaPTP (mutant) + tyrosine<br />
-**[[5ncr]] – PTP (mutant) – ORF virus<br />
-}}
 == References ==
 <references/>
+</StructureSection>
 [[Category:Topic Page]]