6mk2
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Coleus blumei rosmarinic acid synthase (RAS) in complex with 4-coumaroyl-(R)-3-(4-hydroxyphenyl)lactate== | |
| - | + | <StructureSection load='6mk2' size='340' side='right'caption='[[6mk2]], [[Resolution|resolution]] 3.35Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6mk2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plectranthus_scutellarioides Plectranthus scutellarioides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MK2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MK2 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.35Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JUV:(2R)-3-(4-hydroxyphenyl)-2-{[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]oxy}propanoic+acid'>JUV</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mk2 OCA], [https://pdbe.org/6mk2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mk2 RCSB], [https://www.ebi.ac.uk/pdbsum/6mk2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mk2 ProSAT]</span></td></tr> |
| - | [[Category: Levsh | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RAS_PLESU RAS_PLESU] Involved in the biosynthesis of rosmarinic acid, a compound with antiviral, antimicrobial and anti-inflammatory activities. Can use 4-coumaroyl- and caffeoyl-CoA as hydroxycinnamoyl donors and 4-Hydroxyphenyllactate and 3.4-Dihydroxyphenyllactate, but not shikimate or quinate, as hydroxycinnamoyl acceptors. Can also putatively catalyze amide formation with D-amino acids as acceptors.<ref>PMID:17047986</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Plectranthus scutellarioides]] | ||
| + | [[Category: Levsh OL]] | ||
| + | [[Category: Weng JK]] | ||
Current revision
Crystal structure of Coleus blumei rosmarinic acid synthase (RAS) in complex with 4-coumaroyl-(R)-3-(4-hydroxyphenyl)lactate
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