6mks
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6mks is ON HOLD until Paper Publication Authors: Zheng, W., Matyszewski, M., Sohn, J., Egelman, E.H. Description: Cryo-EM structure of NLRC4-CARD f...) |
|||
| (6 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of NLRC4-CARD filament== | |
| + | <SX load='6mks' size='340' side='right' viewer='molstar' caption='[[6mks]], [[Resolution|resolution]] 3.40Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6mks]] is a 31 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MKS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MKS FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mks OCA], [https://pdbe.org/6mks PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mks RCSB], [https://www.ebi.ac.uk/pdbsum/6mks PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mks ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/NLRC4_HUMAN NLRC4_HUMAN] The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NLRC4_HUMAN NLRC4_HUMAN] Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis (PubMed:15107016). The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria (By similarity).[UniProtKB:Q3UP24]<ref>PMID:15107016</ref> [https://www.uniprot.org/uniprot/GFP_AEQVI GFP_AEQVI] Energy-transfer acceptor. Its role is to transduce the blue chemiluminescence of the protein aequorin into green fluorescent light by energy transfer. Fluoresces in vivo upon receiving energy from the Ca(2+)-activated photoprotein aequorin. | ||
| - | + | ==See Also== | |
| - | + | *[[Green Fluorescent Protein 3D structures|Green Fluorescent Protein 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </SX> |
| - | [[Category: Matyszewski | + | [[Category: Homo sapiens]] |
| - | [[Category: Zheng | + | [[Category: Large Structures]] |
| + | [[Category: Vaccinia virus]] | ||
| + | [[Category: Egelman EH]] | ||
| + | [[Category: Matyszewski M]] | ||
| + | [[Category: Sohn J]] | ||
| + | [[Category: Zheng W]] | ||
Current revision
Cryo-EM structure of NLRC4-CARD filament
| |||||||||
