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6a96
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==Cryo-EM structure of the human alpha5beta3 GABAA receptor in complex with GABA and Nb25== | ==Cryo-EM structure of the human alpha5beta3 GABAA receptor in complex with GABA and Nb25== | ||
| - | < | + | <SX load='6a96' size='340' side='right' viewer='molstar' caption='[[6a96]], [[Resolution|resolution]] 3.51Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6a96]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A96 OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[6a96]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A96 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6A96 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABU:GAMMA-AMINO-BUTANOIC+ACID'>ABU</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.51Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABU:GAMMA-AMINO-BUTANOIC+ACID'>ABU</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6a96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a96 OCA], [https://pdbe.org/6a96 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6a96 RCSB], [https://www.ebi.ac.uk/pdbsum/6a96 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6a96 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Disease == | ||
| - | [[http://www.uniprot.org/uniprot/GBRB3_HUMAN GBRB3_HUMAN]] Autism;Childhood absence epilepsy. Disease susceptibility is associated with variations affecting the gene represented in this entry. | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/GBRA5_HUMAN GBRA5_HUMAN] GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. |
| + | |||
| + | ==See Also== | ||
| + | *[[GABA receptor 3D structures|GABA receptor 3D structures]] | ||
__TOC__ | __TOC__ | ||
| - | </ | + | </SX> |
| - | [[Category: Bi | + | [[Category: Homo sapiens]] |
| - | [[Category: Cui | + | [[Category: Lama glama]] |
| - | [[Category: Guan | + | [[Category: Large Structures]] |
| - | [[Category: Liu | + | [[Category: Bi GQ]] |
| - | [[Category: Liu | + | [[Category: Cui Y]] |
| - | [[Category: Xu | + | [[Category: Guan F]] |
| - | [[Category: Ye | + | [[Category: Liu S]] |
| - | [[Category: Zhang | + | [[Category: Liu YT]] |
| - | [[Category: Zhang | + | [[Category: Xu L]] |
| - | [[Category: Zhou | + | [[Category: Ye S]] |
| - | + | [[Category: Zhang Q]] | |
| - | + | [[Category: Zhang X]] | |
| + | [[Category: Zhou ZH]] | ||
Current revision
Cryo-EM structure of the human alpha5beta3 GABAA receptor in complex with GABA and Nb25
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Categories: Homo sapiens | Lama glama | Large Structures | Bi GQ | Cui Y | Guan F | Liu S | Liu YT | Xu L | Ye S | Zhang Q | Zhang X | Zhou ZH
