2qne

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[[Image:2qne.jpg|left|200px]]
 
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{{Structure
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==Crystal structure of putative methyltransferase (ZP_00558420.1) from Desulfitobacterium hafniense Y51 at 2.30 A resolution==
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|PDB= 2qne |SIZE=350|CAPTION= <scene name='initialview01'>2qne</scene>, resolution 2.300&Aring;
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<StructureSection load='2qne' size='340' side='right'caption='[[2qne]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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<table><tr><td colspan='2'>[[2qne]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Desulfitobacterium_hafniense_Y51 Desulfitobacterium hafniense Y51]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QNE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QNE FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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|GENE= ZP_00558420.1, DSY3156 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=138119 Desulfitobacterium hafniense Y51])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG5598 COG5598]</span>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qne OCA], [https://pdbe.org/2qne PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qne RCSB], [https://www.ebi.ac.uk/pdbsum/2qne PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qne ProSAT], [https://www.topsan.org/Proteins/JCSG/2qne TOPSAN]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qne OCA], [http://www.ebi.ac.uk/pdbsum/2qne PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2qne RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/MTGB_DESHY MTGB_DESHY] Methyltransferase able to methylate free cob(I)alamin in vitro, using glycine betaine as the methyl donor, yealding methylcobalamin (methylCbl) and dimethylglycine. In vivo, probably carries out the methylation of a corrinoid protein, likely the adjacently encoded DSY3155, with glycine betaine, to then supply methyl groups to tetrahydrofolate (THF) for ultimate conversion to carbon dioxide; oxidation of the methyl group would also provide reducing equivalents for anaerobic respiration. Thus, may function in the pathway that allows anaerobic methylotrophic growth of D.hafniense using glycine betaine. Cannot use quaternary amines such as carnitine and choline as substrates, nor tertiary amines such as dimethylglycine or trimethylamine.<ref>PMID:25313086</ref>
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== Evolutionary Conservation ==
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'''Crystal structure of putative methyltransferase (ZP_00558420.1) from Desulfitobacterium hafniense Y51 at 2.30 A resolution'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qn/2qne_consurf.spt"</scriptWhenChecked>
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2QNE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Desulfitobacterium_hafniense_y51 Desulfitobacterium hafniense y51]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QNE OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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[[Category: Desulfitobacterium hafniense y51]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Single protein]]
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</jmolCheckbox>
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[[Category: JCSG, Joint Center for Structural Genomics.]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qne ConSurf].
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[[Category: jcsg]]
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<div style="clear:both"></div>
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[[Category: joint center for structural genomic]]
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== References ==
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[[Category: protein structure initiative]]
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<references/>
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[[Category: psi-2]]
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__TOC__
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[[Category: putative methyltransferase]]
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</StructureSection>
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[[Category: structural genomic]]
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[[Category: Desulfitobacterium hafniense Y51]]
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[[Category: uncharacterized protein]]
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[[Category: Large Structures]]
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[[Category: unknown function]]
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[[Category: zp_00558420 1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:51:07 2008''
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Current revision

Crystal structure of putative methyltransferase (ZP_00558420.1) from Desulfitobacterium hafniense Y51 at 2.30 A resolution

PDB ID 2qne

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