2qnk

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:34, 30 October 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2qnk.jpg|left|200px]]
 
-
{{Structure
+
==Crystal structure of human 3-hydroxyanthranilate 3,4-dioxygenase==
-
|PDB= 2qnk |SIZE=350|CAPTION= <scene name='initialview01'>2qnk</scene>, resolution 1.60&Aring;
+
<StructureSection load='2qnk' size='340' side='right'caption='[[2qnk]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
+
<table><tr><td colspan='2'>[[2qnk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QNK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QNK FirstGlance]. <br>
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/3-hydroxyanthranilate_3,4-dioxygenase 3-hydroxyanthranilate 3,4-dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.6 1.13.11.6] </span>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
-
|GENE= HAAO ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam06052 3-HAO]</span>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qnk OCA], [https://pdbe.org/2qnk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qnk RCSB], [https://www.ebi.ac.uk/pdbsum/2qnk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qnk ProSAT], [https://www.topsan.org/Proteins/CESG/2qnk TOPSAN]</span></td></tr>
-
|RELATEDENTRY=
+
</table>
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qnk OCA], [http://www.ebi.ac.uk/pdbsum/2qnk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2qnk RCSB]</span>
+
== Function ==
-
}}
+
[https://www.uniprot.org/uniprot/3HAO_HUMAN 3HAO_HUMAN] Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.<ref>PMID:7514594</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qn/2qnk_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qnk ConSurf].
 +
<div style="clear:both"></div>
-
'''Crystal structure of human 3-hydroxyanthranilate 3,4-dioxygenase'''
+
==See Also==
-
 
+
*[[Dioxygenase 3D structures|Dioxygenase 3D structures]]
-
 
+
== References ==
-
==About this Structure==
+
<references/>
-
2QNK is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QNK OCA].
+
__TOC__
-
[[Category: 3-hydroxyanthranilate 3,4-dioxygenase]]
+
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Protein complex]]
+
[[Category: Large Structures]]
-
[[Category: Bingman, C A.]]
+
[[Category: Bingman CA]]
-
[[Category: Bitto, E.]]
+
[[Category: Bitto E]]
-
[[Category: CESG, Center for Eukaryotic Structural Genomics.]]
+
[[Category: Phillips Jr GN]]
-
[[Category: Jr., G N.Phillips.]]
+
[[Category: Wesenberg GE]]
-
[[Category: Wesenberg, G E.]]
+
-
[[Category: bicupin fold]]
+
-
[[Category: center for eukaryotic structural genomic]]
+
-
[[Category: cesg]]
+
-
[[Category: cupin barrel]]
+
-
[[Category: extradiol dioxygenase]]
+
-
[[Category: kynurenine pathway]]
+
-
[[Category: metalloenzyme]]
+
-
[[Category: nad+ synthesis]]
+
-
[[Category: oxidoreductase]]
+
-
[[Category: protein structure initiative]]
+
-
[[Category: psi]]
+
-
[[Category: quinolinate]]
+
-
[[Category: structural genomics medical relevance]]
+
-
[[Category: trytophan catabolism]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:51:12 2008''
+

Current revision

Crystal structure of human 3-hydroxyanthranilate 3,4-dioxygenase

PDB ID 2qnk

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2qnk"
Personal tools