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5lzw

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Current revision (18:18, 1 November 2023) (edit) (undo)
 
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{{Large structure}}
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==Structure of the mammalian rescue complex with Pelota and Hbs1l assembled on a truncated mRNA.==
==Structure of the mammalian rescue complex with Pelota and Hbs1l assembled on a truncated mRNA.==
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<StructureSection load='5lzw' size='340' side='right' caption='[[5lzw]], [[Resolution|resolution]] 3.53&Aring;' scene=''>
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<SX load='5lzw' size='340' side='right' viewer='molstar' caption='[[5lzw]], [[Resolution|resolution]] 3.53&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5lzw]] is a 87 chain structure with sequence from [http://en.wikipedia.org/wiki/European_rabbit European rabbit] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LZW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LZW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5lzw]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LZW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LZW FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.53&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PELO, CGI-17 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 European rabbit]), HBS1L, HBS1, KIAA1038 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 European rabbit])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lzw OCA], [http://pdbe.org/5lzw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lzw RCSB], [http://www.ebi.ac.uk/pdbsum/5lzw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lzw ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lzw OCA], [https://pdbe.org/5lzw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lzw RCSB], [https://www.ebi.ac.uk/pdbsum/5lzw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lzw ProSAT]</span></td></tr>
</table>
</table>
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{{Large structure}}
 
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/U3KPD5_RABIT U3KPD5_RABIT]] Binds to the 23S rRNA.[RuleBase:RU000576] [[http://www.uniprot.org/uniprot/PELO_HUMAN PELO_HUMAN]] Required for normal chromosome segregation during cell division and genomic stability (By similarity). May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity (Potential). [[http://www.uniprot.org/uniprot/G1SS70_RABIT G1SS70_RABIT]] May play a role during erythropoiesis through regulation of transcription factor DDIT3.[HAMAP-Rule:MF_03122]
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[https://www.uniprot.org/uniprot/G1TT27_RABIT G1TT27_RABIT]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Receptor for activated protein kinase C 1|Receptor for activated protein kinase C 1]]
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*[[3D sructureseceptor for activated protein kinase C 1|3D sructureseceptor for activated protein kinase C 1]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
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</StructureSection>
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</SX>
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[[Category: European rabbit]]
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[[Category: Large Structures]]
[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
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[[Category: Brown, A]]
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[[Category: Brown A]]
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[[Category: Hegde, R S]]
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[[Category: Hegde RS]]
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[[Category: Murray, J]]
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[[Category: Murray J]]
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[[Category: Ramakrishnan, V]]
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[[Category: Ramakrishnan V]]
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[[Category: Shao, S]]
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[[Category: Shao S]]
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[[Category: Taunton, J]]
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[[Category: Taunton J]]
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[[Category: Elongation]]
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[[Category: Ribosome]]
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[[Category: Translation]]
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Current revision

Structure of the mammalian rescue complex with Pelota and Hbs1l assembled on a truncated mRNA.

5lzw, resolution 3.53Å

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