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2xg4

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==E. coli P pilus chaperone-subunit complex PapD-PapH bound to pilus biogenesis inhibitor, pilicide 2c==
==E. coli P pilus chaperone-subunit complex PapD-PapH bound to pilus biogenesis inhibitor, pilicide 2c==
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<StructureSection load='2xg4' size='340' side='right' caption='[[2xg4]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='2xg4' size='340' side='right'caption='[[2xg4]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2xg4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XG4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XG4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2xg4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XG4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XG4 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=XC2:(3R)-8-CYCLOPROPYL-6-(MORPHOLIN-4-YLMETHYL)-7-(1-NAPHTHYLMETHYL)-5-OXO-2,3-DIHYDRO-5H-[1,3]THIAZOLO[3,2-A]PYRIDINE-3-CARBOXYLIC+ACID'>XC2</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2j2z|2j2z]], [[1qpp|1qpp]], [[1qpx|1qpx]], [[2wmp|2wmp]], [[3dpa|3dpa]], [[1pdk|1pdk]], [[1n0l|1n0l]], [[2xg5|2xg5]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=XC2:(3R)-8-CYCLOPROPYL-6-(MORPHOLIN-4-YLMETHYL)-7-(1-NAPHTHYLMETHYL)-5-OXO-2,3-DIHYDRO-5H-[1,3]THIAZOLO[3,2-A]PYRIDINE-3-CARBOXYLIC+ACID'>XC2</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xg4 OCA], [http://pdbe.org/2xg4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xg4 RCSB], [http://www.ebi.ac.uk/pdbsum/2xg4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xg4 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xg4 OCA], [https://pdbe.org/2xg4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xg4 RCSB], [https://www.ebi.ac.uk/pdbsum/2xg4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xg4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PAPD_ECOLX PAPD_ECOLX]] Binds and caps interactive surfaces on pilus subunits to prevent them from participating in non-productive interactions. Facilitates the import of subunits into the periplasm. May facilitate subunit folding. Chaperone-subunit complexes are then targeted to the PapC outer membrane usher where the chaperone must uncap from the subunits. [[http://www.uniprot.org/uniprot/PAPH_ECOLX PAPH_ECOLX]] Fimbriae (also called pili), polar filaments radiating from the surface of the bacterium to a length of 0.5-1.5 micrometers and numbering 100-300 per cell, enable bacteria to colonize the epithelium of specific host organs. PapH seems to anchor the pilus to the bacterial cell. In addition the stoichiometric relationship between PapH and PapA determines the pilus length.
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[https://www.uniprot.org/uniprot/PAPD_ECOLX PAPD_ECOLX] Binds and caps interactive surfaces on pilus subunits to prevent them from participating in non-productive interactions. Facilitates the import of subunits into the periplasm. May facilitate subunit folding. Chaperone-subunit complexes are then targeted to the PapC outer membrane usher where the chaperone must uncap from the subunits.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Pilin|Pilin]]
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*[[Pilin 3D structures|Pilin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
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[[Category: Almqvist, F]]
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[[Category: Large Structures]]
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[[Category: Buelens, F]]
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[[Category: Almqvist F]]
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[[Category: Chorell, E]]
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[[Category: Buelens F]]
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[[Category: Edvinsson, S]]
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[[Category: Chorell E]]
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[[Category: Hultgren, S J]]
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[[Category: Edvinsson S]]
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[[Category: Phan, G]]
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[[Category: Hultgren SJ]]
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[[Category: Pinkner, J S]]
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[[Category: Phan G]]
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[[Category: Remaut, H]]
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[[Category: Pinkner JS]]
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[[Category: Waksman, G]]
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[[Category: Remaut H]]
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[[Category: Chaperone]]
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[[Category: Waksman G]]
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[[Category: Chaperone-surface active protein complex]]
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Current revision

E. coli P pilus chaperone-subunit complex PapD-PapH bound to pilus biogenesis inhibitor, pilicide 2c

PDB ID 2xg4

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