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2xkk

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==CRYSTAL STRUCTURE OF MOXIFLOXACIN, DNA, and A. BAUMANNII TOPO IV (PARE-PARC FUSION TRUNCATE)==
==CRYSTAL STRUCTURE OF MOXIFLOXACIN, DNA, and A. BAUMANNII TOPO IV (PARE-PARC FUSION TRUNCATE)==
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<StructureSection load='2xkk' size='340' side='right' caption='[[2xkk]], [[Resolution|resolution]] 3.25&Aring;' scene=''>
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<StructureSection load='2xkk' size='340' side='right'caption='[[2xkk]], [[Resolution|resolution]] 3.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2xkk]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Acibs Acibs]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XKK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XKK FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2xkk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii Acinetobacter baumannii] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XKK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XKK FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MFX:1-CYCLOPROPYL-6-FLUORO-8-METHOXY-7-[(4AS,7AS)-OCTAHYDRO-6H-PYRROLO[3,4-B]PYRIDIN-6-YL]-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC+ACID'>MFX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.25&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MFX:1-CYCLOPROPYL-6-FLUORO-8-METHOXY-7-[(4AS,7AS)-OCTAHYDRO-6H-PYRROLO[3,4-B]PYRIDIN-6-YL]-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC+ACID'>MFX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2xkj|2xkj]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xkk OCA], [https://pdbe.org/2xkk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xkk RCSB], [https://www.ebi.ac.uk/pdbsum/2xkk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xkk ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xkk OCA], [http://pdbe.org/2xkk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xkk RCSB], [http://www.ebi.ac.uk/pdbsum/2xkk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xkk ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/B0V9T6_ACIBY B0V9T6_ACIBY] [https://www.uniprot.org/uniprot/B0VP98_ACIBS B0VP98_ACIBS] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.[HAMAP-Rule:MF_00936]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Topoisomerase|Topoisomerase]]
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*[[Topoisomerase 3D structures|Topoisomerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Acibs]]
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[[Category: Acinetobacter baumannii]]
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[[Category: Bax, B D]]
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[[Category: Large Structures]]
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[[Category: Chan, P F]]
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[[Category: Synthetic construct]]
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[[Category: Fosberry, A P]]
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[[Category: Bax BD]]
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[[Category: Gwynn, M N]]
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[[Category: Chan PF]]
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[[Category: Homes, P]]
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[[Category: Fosberry AP]]
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[[Category: Huang, J]]
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[[Category: Gwynn MN]]
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[[Category: Kranz, M]]
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[[Category: Homes P]]
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[[Category: Leydon, V R]]
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[[Category: Huang J]]
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[[Category: Miles, T J]]
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[[Category: Kranz M]]
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[[Category: Pearson, N D]]
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[[Category: Leydon VR]]
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[[Category: Perera, R L]]
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[[Category: Miles TJ]]
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[[Category: Shillings, A J]]
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[[Category: Pearson ND]]
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[[Category: Wohlkonig, A]]
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[[Category: Perera RL]]
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[[Category: Antibacterial agent]]
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[[Category: Shillings AJ]]
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[[Category: Isomerase-dna-antibiotic complex]]
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[[Category: Wohlkonig A]]
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[[Category: Quinolone]]
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[[Category: Type iia topoisomerase]]
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Current revision

CRYSTAL STRUCTURE OF MOXIFLOXACIN, DNA, and A. BAUMANNII TOPO IV (PARE-PARC FUSION TRUNCATE)

PDB ID 2xkk

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