Uridylate kinase
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
| - | The biological assembly of Uridylate kinase from ''Sulfolobus solfataricus'' ([[2j4k]]) is <scene name='48/487531/Cv/ | + | The biological assembly of Uridylate kinase from ''Sulfolobus solfataricus'' ([[2j4k]]) is <scene name='48/487531/Cv/4'>homohexamer</scene>. The <scene name='48/487531/Cv/5'>active site of UK has high specificity to uracil</scene> and excludes purine nucleotides<ref>PMID:17297917</ref>. Water molecule is shown as red sphere. |
</StructureSection> | </StructureSection> | ||
==3D structures of uridylate kinase== | ==3D structures of uridylate kinase== | ||
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*Uridylate kinase complex with nucleotides | *Uridylate kinase complex with nucleotides | ||
| + | **[[1uky]] – yUK + ADP – yeast<br /> | ||
**[[1ukz]] – yUK + AMP + ADP<br /> | **[[1ukz]] – yUK + AMP + ADP<br /> | ||
**[[2bne]] – EcUK (mutant) + UMP – ''Escherichia coli''<br /> | **[[2bne]] – EcUK (mutant) + UMP – ''Escherichia coli''<br /> | ||
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**[[2j4l]] - SsUK + UTP<br /> | **[[2j4l]] - SsUK + UTP<br /> | ||
**[[2jjx]] - UK + ATP + Mg – ''Bacillus anthracis''<br /> | **[[2jjx]] - UK + ATP + Mg – ''Bacillus anthracis''<br /> | ||
| - | **[[1uky]] – yUK + ADP – yeast<br /> | ||
**[[3ek5]] - XcUK + GTP <br /> | **[[3ek5]] - XcUK + GTP <br /> | ||
| - | **[[3nwy]] – | + | **[[3nwy]] – MtUK + UTP + GTP – ''Mycobacterium tuberculosis''<br /> |
| + | **[[7bex]], [[7bix]], [[7bl7]] - MtUK + UTP + UDP<br /> | ||
**[[4a7x]], [[4a7w]] - UK + UDP – ''Helicobacter pylori''<br /> | **[[4a7x]], [[4a7w]] - UK + UDP – ''Helicobacter pylori''<br /> | ||
}} | }} | ||
Current revision
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3D structures of uridylate kinase
Updated on 21-June-2022
References
- ↑ Yan H, Tsai MD. Nucleoside monophosphate kinases: structure, mechanism, and substrate specificity. Adv Enzymol Relat Areas Mol Biol. 1999;73:103-34, x. PMID:10218107
- ↑ Jensen KS, Johansson E, Jensen KF. Structural and enzymatic investigation of the Sulfolobus solfataricus uridylate kinase shows competitive UTP inhibition and the lack of GTP stimulation. Biochemistry. 2007 Mar 13;46(10):2745-57. Epub 2007 Feb 13. PMID:17297917 doi:10.1021/bi0618159
