2qxf

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[[Image:2qxf.jpg|left|200px]]
 
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{{Structure
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==Product bound structure of exonuclease I at 1.5 angstrom resolution==
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|PDB= 2qxf |SIZE=350|CAPTION= <scene name='initialview01'>2qxf</scene>, resolution 1.50&Aring;
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<StructureSection load='2qxf' size='340' side='right'caption='[[2qxf]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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|SITE= <scene name='pdbsite=AC1:Mg+Binding+Site+For+Residue+A+2000'>AC1</scene>, <scene name='pdbsite=AC2:Mg+Binding+Site+For+Residue+A+2001'>AC2</scene>, <scene name='pdbsite=AC3:Na+Binding+Site+For+Residue+A+2002'>AC3</scene> and <scene name='pdbsite=AC4:Tmp+Binding+Site+For+Residue+A+3000'>AC4</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TMP:THYMIDINE-5&#39;-PHOSPHATE'>TMP</scene>
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<table><tr><td colspan='2'>[[2qxf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QXF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QXF FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Exodeoxyribonuclease_I Exodeoxyribonuclease I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.11.1 3.1.11.1] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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|GENE= sbcB, cpeA, xonA, b2011, JW1993 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 Escherichia coli K12])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TMP:THYMIDINE-5-PHOSPHATE'>TMP</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qxf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qxf OCA], [https://pdbe.org/2qxf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qxf RCSB], [https://www.ebi.ac.uk/pdbsum/2qxf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qxf ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qxf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qxf OCA], [http://www.ebi.ac.uk/pdbsum/2qxf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2qxf RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/EX1_ECOLI EX1_ECOLI] Also functions as a DNA deoxyribophosphodiesterase that releases deoxyribose-phosphate moieties following the cleavage DNA at an apurinic/apyrimidinic (AP) site by either an AP endonuclease AP lyase.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qx/2qxf_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qxf ConSurf].
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<div style="clear:both"></div>
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'''Product bound structure of exonuclease I at 1.5 angstrom resolution'''
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==See Also==
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*[[Exonuclease 3D structures|Exonuclease 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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2QXF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k12 Escherichia coli k12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QXF OCA].
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[[Category: Escherichia coli K-12]]
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[[Category: Escherichia coli k12]]
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[[Category: Large Structures]]
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[[Category: Exodeoxyribonuclease I]]
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[[Category: Busam RD]]
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[[Category: Single protein]]
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[[Category: Busam, R D.]]
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[[Category: alpha-beta domain]]
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[[Category: dna damage]]
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[[Category: dna repair]]
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[[Category: dnaq superfamily]]
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[[Category: exonuclease]]
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[[Category: hydrolase]]
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[[Category: nuclease]]
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[[Category: product bound structure]]
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[[Category: sh3-like domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:54:25 2008''
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Current revision

Product bound structure of exonuclease I at 1.5 angstrom resolution

PDB ID 2qxf

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