5qdh

From Proteopedia

(Difference between revisions)

Current revision

PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000004a

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5qdh"

@@ Line 1: / Line 1: @@
 ==PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000004a==
-<StructureSection load='5qdh' size='340' side='right' caption='[[5qdh]], [[Resolution|resolution]] 1.68&Aring;' scene=''>
+<StructureSection load='5qdh' size='340' side='right'caption='[[5qdh]], [[Resolution|resolution]] 1.68&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5qdh]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QDH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5QDH FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5qdh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QDH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QDH FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JFJ:1-(3-chlorophenyl)-N-methylmethanamine'>JFJ</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.682&#8491;</td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JFJ:1-(3-chlorophenyl)-N-methylmethanamine'>JFJ</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5qdh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qdh OCA], [http://pdbe.org/5qdh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5qdh RCSB], [http://www.ebi.ac.uk/pdbsum/5qdh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5qdh ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qdh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qdh OCA], [https://pdbe.org/5qdh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qdh RCSB], [https://www.ebi.ac.uk/pdbsum/5qdh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qdh ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN]] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>
+[https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>
+==See Also==
+*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Protein-tyrosine-phosphatase]]
+[[Category: Homo sapiens]]
-[[Category: Biel, J T]]
+[[Category: Large Structures]]
-[[Category: Brandao-Neto, J]]
+[[Category: Biel JT]]
-[[Category: Delft, F von]]
+[[Category: Brandao-Neto J]]
-[[Category: Fraser, J S]]
+[[Category: Fraser JS]]
-[[Category: Hill, Z B]]
+[[Category: Hill ZB]]
-[[Category: Kang, E]]
+[[Category: Kang E]]
-[[Category: Keedy, D A]]
+[[Category: Keedy DA]]
-[[Category: Rettenmaier, T J]]
+[[Category: Rettenmaier TJ]]
-[[Category: Wells, J A]]
+[[Category: Wells JA]]
-[[Category: Allostery]]
+[[Category: Von Delft F]]
-[[Category: Enzyme]]
-[[Category: Hydrolase]]
-[[Category: Multiconformer]]
-[[Category: Pandda]]
-[[Category: Protein tyrosine phosphatase]]
-[[Category: Protein tyrosine phosphatase 1b]]
-[[Category: Ptp]]
-[[Category: Ptp1b]]
-[[Category: Sgc - diamond i04-1 fragment screening]]

5qdh

From Proteopedia

Current revision

PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000004a

Structural highlights

Function

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

Personal tools

Navigation

Search

Toolbox