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5qe4
From Proteopedia
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==PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000514a== | ==PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000514a== | ||
| - | <StructureSection load='5qe4' size='340' side='right' caption='[[5qe4]], [[Resolution|resolution]] 1.85Å' scene=''> | + | <StructureSection load='5qe4' size='340' side='right'caption='[[5qe4]], [[Resolution|resolution]] 1.85Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5qe4]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QE4 OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[5qe4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QE4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QE4 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.852Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JH4:N-methylpyrimidin-2-amine'>JH4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qe4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qe4 OCA], [https://pdbe.org/5qe4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qe4 RCSB], [https://www.ebi.ac.uk/pdbsum/5qe4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qe4 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref> |
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| + | ==See Also== | ||
| + | *[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Biel JT]] |
| - | [[Category: | + | [[Category: Brandao-Neto J]] |
| - | [[Category: Fraser | + | [[Category: Fraser JS]] |
| - | [[Category: Hill | + | [[Category: Hill ZB]] |
| - | [[Category: Kang | + | [[Category: Kang E]] |
| - | [[Category: Keedy | + | [[Category: Keedy DA]] |
| - | [[Category: Rettenmaier | + | [[Category: Rettenmaier TJ]] |
| - | [[Category: Wells | + | [[Category: Wells JA]] |
| - | [[Category: | + | [[Category: Von Delft F]] |
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Current revision
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000514a
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Categories: Homo sapiens | Large Structures | Biel JT | Brandao-Neto J | Fraser JS | Hill ZB | Kang E | Keedy DA | Rettenmaier TJ | Wells JA | Von Delft F
