5z8y

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (12:23, 6 November 2024) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
-
==Crystal structure of a synaptic protein complex==
+
==Crystal structure of human LRRTM2 in complex with Neurexin 1beta==
-
<StructureSection load='5z8y' size='340' side='right' caption='[[5z8y]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
+
<StructureSection load='5z8y' size='340' side='right'caption='[[5z8y]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5z8y]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z8Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Z8Y FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5z8y]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z8Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5Z8Y FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5z8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z8y OCA], [http://pdbe.org/5z8y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5z8y RCSB], [http://www.ebi.ac.uk/pdbsum/5z8y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5z8y ProSAT]</span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5z8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z8y OCA], [https://pdbe.org/5z8y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5z8y RCSB], [https://www.ebi.ac.uk/pdbsum/5z8y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5z8y ProSAT]</span></td></tr>
</table>
</table>
-
== Disease ==
 
-
[[http://www.uniprot.org/uniprot/NRX1B_HUMAN NRX1B_HUMAN]] Pitt-Hopkins-like syndrome;Autism;Schizophrenia.
 
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/LRRT2_HUMAN LRRT2_HUMAN]] Involved in the development and maintenance of excitatory synapse in the vertebrate nervous system. Regulates surface expression of AMPA receptors and instructs the development of functional glutamate release sites. Acts as a ligand for the presynaptic receptors NRXN1-A and NRXN1-B (By similarity). [[http://www.uniprot.org/uniprot/NRX1B_HUMAN NRX1B_HUMAN]] Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis (By similarity).
+
[https://www.uniprot.org/uniprot/LRRT2_HUMAN LRRT2_HUMAN] Involved in the development and maintenance of excitatory synapse in the vertebrate nervous system. Regulates surface expression of AMPA receptors and instructs the development of functional glutamate release sites. Acts as a ligand for the presynaptic receptors NRXN1-A and NRXN1-B (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 20: Line 19:
</div>
</div>
<div class="pdbe-citations 5z8y" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5z8y" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Neurexin|Neurexin]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Fukai, S]]
+
[[Category: Homo sapiens]]
-
[[Category: Yamagata, A]]
+
[[Category: Large Structures]]
-
[[Category: Cell adhesion]]
+
[[Category: Fukai S]]
-
[[Category: Leucine-rich repeat]]
+
[[Category: Yamagata A]]
-
[[Category: Synapse]]
+
-
[[Category: Synaptic organizer]]
+

Current revision

Crystal structure of human LRRTM2 in complex with Neurexin 1beta

PDB ID 5z8y

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5z8y"
Personal tools