5zoj

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:28, 27 March 2024) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
==Crystal structure of human SMAD2-MAN1 complex==
==Crystal structure of human SMAD2-MAN1 complex==
-
<StructureSection load='5zoj' size='340' side='right' caption='[[5zoj]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
+
<StructureSection load='5zoj' size='340' side='right'caption='[[5zoj]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5zoj]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZOJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZOJ FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5zoj]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZOJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZOJ FirstGlance]. <br>
-
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zoj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zoj OCA], [http://pdbe.org/5zoj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zoj RCSB], [http://www.ebi.ac.uk/pdbsum/5zoj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zoj ProSAT]</span></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.794&#8491;</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zoj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zoj OCA], [https://pdbe.org/5zoj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zoj RCSB], [https://www.ebi.ac.uk/pdbsum/5zoj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zoj ProSAT]</span></td></tr>
</table>
</table>
-
== Disease ==
 
-
[[http://www.uniprot.org/uniprot/MAN1_HUMAN MAN1_HUMAN]] Isolated osteopoikilosis;Buschke-Ollendorff syndrome;12q14 microdeletion syndrome;Melorheostosis with osteopoikilosis. The disease is caused by mutations affecting the gene represented in this entry.
 
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/SMAD2_HUMAN SMAD2_HUMAN]] Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.<ref>PMID:9892009</ref> <ref>PMID:16751101</ref> <ref>PMID:17327236</ref> <ref>PMID:16862174</ref> <ref>PMID:19289081</ref> [[http://www.uniprot.org/uniprot/MAN1_HUMAN MAN1_HUMAN]] Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest.<ref>PMID:15601644</ref> <ref>PMID:15647271</ref>
+
[https://www.uniprot.org/uniprot/SMAD2_HUMAN SMAD2_HUMAN] Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.<ref>PMID:9892009</ref> <ref>PMID:16751101</ref> <ref>PMID:17327236</ref> <ref>PMID:16862174</ref> <ref>PMID:19289081</ref>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Ito, T]]
+
[[Category: Homo sapiens]]
-
[[Category: Miyazono, K]]
+
[[Category: Large Structures]]
-
[[Category: Ohno, Y]]
+
[[Category: Ito T]]
-
[[Category: Tanokura, M]]
+
[[Category: Miyazono K]]
-
[[Category: Complex]]
+
[[Category: Ohno Y]]
-
[[Category: Dna binding protein]]
+
[[Category: Tanokura M]]
-
[[Category: Tgf-beta signaling]]
+
-
[[Category: Transcription]]
+

Current revision

Crystal structure of human SMAD2-MAN1 complex

PDB ID 5zoj

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5zoj"
Personal tools