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5zoj

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==Crystal structure of human SMAD2-MAN1 complex==
==Crystal structure of human SMAD2-MAN1 complex==
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<StructureSection load='5zoj' size='340' side='right' caption='[[5zoj]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
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<StructureSection load='5zoj' size='340' side='right'caption='[[5zoj]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5zoj]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZOJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZOJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5zoj]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZOJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZOJ FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zoj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zoj OCA], [http://pdbe.org/5zoj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zoj RCSB], [http://www.ebi.ac.uk/pdbsum/5zoj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zoj ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.794&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zoj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zoj OCA], [https://pdbe.org/5zoj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zoj RCSB], [https://www.ebi.ac.uk/pdbsum/5zoj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zoj ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
 
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[[http://www.uniprot.org/uniprot/MAN1_HUMAN MAN1_HUMAN]] Isolated osteopoikilosis;Buschke-Ollendorff syndrome;12q14 microdeletion syndrome;Melorheostosis with osteopoikilosis. The disease is caused by mutations affecting the gene represented in this entry.
 
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SMAD2_HUMAN SMAD2_HUMAN]] Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.<ref>PMID:9892009</ref> <ref>PMID:16751101</ref> <ref>PMID:17327236</ref> <ref>PMID:16862174</ref> <ref>PMID:19289081</ref> [[http://www.uniprot.org/uniprot/MAN1_HUMAN MAN1_HUMAN]] Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest.<ref>PMID:15601644</ref> <ref>PMID:15647271</ref>
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[https://www.uniprot.org/uniprot/SMAD2_HUMAN SMAD2_HUMAN] Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.<ref>PMID:9892009</ref> <ref>PMID:16751101</ref> <ref>PMID:17327236</ref> <ref>PMID:16862174</ref> <ref>PMID:19289081</ref>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ito, T]]
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[[Category: Homo sapiens]]
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[[Category: Miyazono, K]]
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[[Category: Large Structures]]
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[[Category: Ohno, Y]]
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[[Category: Ito T]]
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[[Category: Tanokura, M]]
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[[Category: Miyazono K]]
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[[Category: Complex]]
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[[Category: Ohno Y]]
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[[Category: Dna binding protein]]
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[[Category: Tanokura M]]
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[[Category: Tgf-beta signaling]]
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[[Category: Transcription]]
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Current revision

Crystal structure of human SMAD2-MAN1 complex

PDB ID 5zoj

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