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2r37

From Proteopedia

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[[Image:2r37.jpg|left|200px]]
 
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{{Structure
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==Crystal structure of human glutathione peroxidase 3 (selenocysteine to glycine mutant)==
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|PDB= 2r37 |SIZE=350|CAPTION= <scene name='initialview01'>2r37</scene>, resolution 1.85&Aring;
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<StructureSection load='2r37' size='340' side='right'caption='[[2r37]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>
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<table><tr><td colspan='2'>[[2r37]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R37 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R37 FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_peroxidase Glutathione peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.9 1.11.1.9] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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|GENE= GPX3, GPXP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r37 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r37 OCA], [https://pdbe.org/2r37 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r37 RCSB], [https://www.ebi.ac.uk/pdbsum/2r37 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r37 ProSAT]</span></td></tr>
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|RELATEDENTRY=[[2i3y|2I3Y]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r37 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r37 OCA], [http://www.ebi.ac.uk/pdbsum/2r37 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2r37 RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/GPX3_HUMAN GPX3_HUMAN] Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r3/2r37_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r37 ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of human glutathione peroxidase 3 (selenocysteine to glycine mutant)'''
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==See Also==
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*[[Glutathione peroxidase|Glutathione peroxidase]]
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__TOC__
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==About this Structure==
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</StructureSection>
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2R37 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R37 OCA].
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[[Category: Glutathione peroxidase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith CH]]
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[[Category: Delft, F von.]]
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[[Category: Edwards AM]]
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[[Category: Edwards, A M.]]
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[[Category: Gileadi O]]
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[[Category: Gileadi, O.]]
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[[Category: Guo K]]
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[[Category: Guo, K.]]
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[[Category: Johannson C]]
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[[Category: Johannson, C.]]
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[[Category: Kavanagh KL]]
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[[Category: Kavanagh, K L.]]
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[[Category: Oppermann U]]
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[[Category: Oppermann, U.]]
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[[Category: Pike ACW]]
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[[Category: Pike, A C.W.]]
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[[Category: Pilka ES]]
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[[Category: Pilka, E S.]]
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[[Category: Rojkowa A]]
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[[Category: Rojkowa, A.]]
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[[Category: Sundstrom M]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Weigelt J]]
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[[Category: Sundstrom, M.]]
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[[Category: Von Delft F]]
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[[Category: Weigelt, J.]]
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[[Category: glutathione]]
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[[Category: oxidoreductase]]
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[[Category: peroxidase]]
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[[Category: plasma]]
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[[Category: polymorphism]]
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[[Category: secreted]]
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[[Category: selenium]]
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[[Category: selenocysteine]]
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[[Category: sgc]]
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[[Category: structural genomics consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:56:01 2008''
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Current revision

Crystal structure of human glutathione peroxidase 3 (selenocysteine to glycine mutant)

PDB ID 2r37

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