5yk5
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==structure of the human Lamtor4-Lamtor5 complex== | |
| + | <StructureSection load='5yk5' size='340' side='right'caption='[[5yk5]], [[Resolution|resolution]] 2.03Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5yk5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YK5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YK5 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.03Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5yk5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yk5 OCA], [https://pdbe.org/5yk5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5yk5 RCSB], [https://www.ebi.ac.uk/pdbsum/5yk5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5yk5 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/LTOR4_HUMAN LTOR4_HUMAN] As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.<ref>PMID:22980980</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Ragulator complex 3D structures|Ragulator complex 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: Mu | + | __TOC__ |
| - | [[Category: Wu | + | </StructureSection> |
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mu Z]] | ||
| + | [[Category: Wu G]] | ||
Current revision
structure of the human Lamtor4-Lamtor5 complex
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