6if4
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Tbtudor== | |
| + | <StructureSection load='6if4' size='340' side='right'caption='[[6if4]], [[Resolution|resolution]] 1.93Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6if4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei_TREU927 Trypanosoma brucei brucei TREU927]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IF4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IF4 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.934Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6if4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6if4 OCA], [https://pdbe.org/6if4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6if4 RCSB], [https://www.ebi.ac.uk/pdbsum/6if4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6if4 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/D6XIY7_TRYB2 D6XIY7_TRYB2] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The essential SAS2-related acetyltransferase 1 (Esa1), as a acetyltransferase of MYST family, is indispensable for the cell cycle and transcriptional regulation. The Tudor domain consists of 60 amino acids and belongs to the Royal family, which serves as a module interacting with methylated histone and/or DNA. Although Tudor domain has been widely studied in higher eukaryotes, its structure and function remain unclear in Trypanosoma brucei (T. brucei), a protozoan unicellular parasite causing sleeping sickness in human and nagana in cattle in sub-Saharan Africa. Here, we determined a high-resolution structure of TbEsa1 presumed Tudor domain from T. brucei by X-ray crystallography. TbEsa1 Tudor domain adopts a conserved Tudor-like fold, which is comprised of a five-stranded beta-barrel surrounded by two short alpha-helices. Furthermore, we revealed a non-specific DNA binding pattern of TbEsa1 Tudor domain. However, TbEsa1 Tudor domain showed no methyl-histone binding ability, due to the absence of key aromatic residues forming a conserved aromatic cage. | ||
| - | + | Crystal structure of TbEsa1 presumed Tudor domain from Trypanosoma brucei.,Gao J, Ye K, Diwu Y, Xu C, Zhang X, Liao S, Tu X J Struct Biol. 2020 Jan 1;209(1):107406. doi: 10.1016/j.jsb.2019.107406. Epub, 2019 Nov 17. PMID:31747559<ref>PMID:31747559</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 6if4" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | |
| - | [[Category: | + | ==See Also== |
| - | [[Category: Liao | + | *[[Histone acetyltransferase 3D structures|Histone acetyltransferase 3D structures]] |
| - | [[Category: | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Trypanosoma brucei brucei TREU927]] | ||
| + | [[Category: Diwu Y]] | ||
| + | [[Category: Gao J]] | ||
| + | [[Category: Liao S]] | ||
| + | [[Category: Tu X]] | ||
| + | [[Category: Ye K]] | ||
Current revision
Crystal structure of Tbtudor
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