6mju
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==human cGAS catalytic domain bound with the inhibitor G108== | |
| + | <StructureSection load='6mju' size='340' side='right'caption='[[6mju]], [[Resolution|resolution]] 2.45Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6mju]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MJU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MJU FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JUM:1-[6,7-dichloro-9-(1H-pyrazol-4-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl]-2-hydroxyethan-1-one'>JUM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mju FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mju OCA], [https://pdbe.org/6mju PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mju RCSB], [https://www.ebi.ac.uk/pdbsum/6mju PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mju ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CGAS_HUMAN CGAS_HUMAN] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.<ref>PMID:21478870</ref> <ref>PMID:23258413</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Cyclic GMP-AMP synthase 3D synthase|Cyclic GMP-AMP synthase 3D synthase]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Adura C]] | ||
| + | [[Category: Aida J]] | ||
| + | [[Category: Asano Y]] | ||
| + | [[Category: Gao P]] | ||
| + | [[Category: Glickman JF]] | ||
| + | [[Category: Gogakos T]] | ||
| + | [[Category: Hashizume S]] | ||
| + | [[Category: Imaeda T]] | ||
| + | [[Category: Jennings AJ]] | ||
| + | [[Category: Kamei T]] | ||
| + | [[Category: Kuroita T]] | ||
| + | [[Category: Kuryavyi V]] | ||
| + | [[Category: Lama L]] | ||
| + | [[Category: Meinke P]] | ||
| + | [[Category: Michinom M]] | ||
| + | [[Category: Miller M]] | ||
| + | [[Category: Okamoto R]] | ||
| + | [[Category: Patel DJ]] | ||
| + | [[Category: Ramos-Espiritu L]] | ||
| + | [[Category: Stamford A]] | ||
| + | [[Category: Steinberg JI]] | ||
| + | [[Category: Tomita D]] | ||
| + | [[Category: Tuschl T]] | ||
| + | [[Category: Xie W]] | ||
Current revision
human cGAS catalytic domain bound with the inhibitor G108
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Categories: Homo sapiens | Large Structures | Adura C | Aida J | Asano Y | Gao P | Glickman JF | Gogakos T | Hashizume S | Imaeda T | Jennings AJ | Kamei T | Kuroita T | Kuryavyi V | Lama L | Meinke P | Michinom M | Miller M | Okamoto R | Patel DJ | Ramos-Espiritu L | Stamford A | Steinberg JI | Tomita D | Tuschl T | Xie W
