6mpz

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: '''Unreleased structure''' The entry 6mpz is ON HOLD Authors: Dong, S.-H., Nair, S.K. Description: Crystal structure of a double glycine motif protease from AMS/PCAT transporter in com...)
Current revision (09:46, 2 April 2025) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 6mpz is ON HOLD
+
==Crystal structure of a double glycine motif protease from AMS/PCAT transporter in complex with the leader peptide==
 +
<StructureSection load='6mpz' size='340' side='right'caption='[[6mpz]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[6mpz]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Lachnospiraceae_bacterium_C6A11 Lachnospiraceae bacterium C6A11] and [https://en.wikipedia.org/wiki/Prochlorococcus_marinus_str._MIT_9313 Prochlorococcus marinus str. MIT 9313]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MPZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MPZ FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=16P:3,6,9,12,15,18-HEXAOXAICOSANE'>16P</scene>, <scene name='pdbligand=GLZ:AMINO-ACETALDEHYDE'>GLZ</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mpz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mpz OCA], [https://pdbe.org/6mpz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mpz RCSB], [https://www.ebi.ac.uk/pdbsum/6mpz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mpz ProSAT]</span></td></tr>
 +
</table>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The secretion of peptides and proteins is essential for survival and ecological adaptation of bacteria. Dual-functional ATP-binding cassette transporters export antimicrobial or quorum signaling peptides in Gram-positive bacteria. Their substrates contain a leader sequence that is excised by an N-terminal peptidase C39 domain at a double Gly motif. We characterized the protease domain (LahT150) of a transporter from a lanthipeptide biosynthetic operon in Lachnospiraceae and demonstrate that this protease can remove the leader peptide from a diverse set of peptides. The 2.0 A resolution crystal structure of the protease domain in complex with a covalently bound leader peptide demonstrates the basis for substrate recognition across the entire class of such transporters. The structural data also provide a model for understanding the role of leader peptide recognition in the translocation cycle, and the function of degenerate, non-functional C39-like domains (CLD) in substrate recruitment in toxin exporters in Gram-negative bacteria.
-
Authors: Dong, S.-H., Nair, S.K.
+
Insights into AMS/PCAT transporters from biochemical and structural characterization of a double Glycine motif protease.,Bobeica SC, Dong SH, Huo L, Mazo N, McLaughlin MI, Jimenez-Oses G, Nair SK, van der Donk WA Elife. 2019 Jan 14;8. pii: 42305. doi: 10.7554/eLife.42305. PMID:30638446<ref>PMID:30638446</ref>
-
Description: Crystal structure of a double glycine motif protease from AMS/PCAT transporter in complex with the leader peptide
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
[[Category: Unreleased Structures]]
+
</div>
-
[[Category: Nair, S.K]]
+
<div class="pdbe-citations 6mpz" style="background-color:#fffaf0;"></div>
-
[[Category: Dong, S.-H]]
+
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Lachnospiraceae bacterium C6A11]]
 +
[[Category: Large Structures]]
 +
[[Category: Prochlorococcus marinus str. MIT 9313]]
 +
[[Category: Dong S-H]]
 +
[[Category: Nair SK]]

Current revision

Crystal structure of a double glycine motif protease from AMS/PCAT transporter in complex with the leader peptide

PDB ID 6mpz

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6mpz"
Personal tools