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6e05

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==Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with cytidine triphosphate solved by precipitant-ligand exchange (crystals grown in sulfate precipitant)==
==Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with cytidine triphosphate solved by precipitant-ligand exchange (crystals grown in sulfate precipitant)==
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<StructureSection load='6e05' size='340' side='right' caption='[[6e05]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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<StructureSection load='6e05' size='340' side='right'caption='[[6e05]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6e05]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E05 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6E05 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6e05]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E05 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6E05 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CTP:CYTIDINE-5-TRIPHOSPHATE'>CTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4wop|4wop]], [[6cve|6cve]], [[6cvu|6cvu]], [[6cvv|6cvv]], [[6cze|6cze]], [[6czb|6czb]], [[6czc|6czc]], [[6cvf|6cvf]], [[6czd|6czd]], [[6e06|6e06]], [[3fgn|3fgn]], [[3fmf|3fmf]], [[3fpa|3fpa]], [[3fmi|3fmi]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CTP:CYTIDINE-5-TRIPHOSPHATE'>CTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dethiobiotin_synthase Dethiobiotin synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.3.3 6.3.3.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6e05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e05 OCA], [https://pdbe.org/6e05 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6e05 RCSB], [https://www.ebi.ac.uk/pdbsum/6e05 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6e05 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6e05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e05 OCA], [http://pdbe.org/6e05 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6e05 RCSB], [http://www.ebi.ac.uk/pdbsum/6e05 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6e05 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BIOD_MYCTU BIOD_MYCTU]] Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring.<ref>PMID:20565114</ref>
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[https://www.uniprot.org/uniprot/BIOD_MYCTU BIOD_MYCTU] Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring.<ref>PMID:20565114</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6e05" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6e05" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Dethiobiotin synthetase 3D structures|Dethiobiotin synthetase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Dethiobiotin synthase]]
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[[Category: Large Structures]]
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[[Category: Bruning, J B]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Polyak, S W]]
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[[Category: Bruning JB]]
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[[Category: Thompson, A P]]
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[[Category: Polyak SW]]
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[[Category: Wegener, K L]]
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[[Category: Thompson AP]]
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[[Category: Enzyme]]
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[[Category: Wegener KL]]
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[[Category: Nucleotide triphosphate binding]]
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[[Category: Synthetase]]
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[[Category: Transferase]]
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Current revision

Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with cytidine triphosphate solved by precipitant-ligand exchange (crystals grown in sulfate precipitant)

PDB ID 6e05

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