6hvd

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(New page: ==Human SLK bound to a maleimide inhibitor== <StructureSection load='6hvd' size='340' side='right' caption='6hvd, resolution 1.63&Aring;' scene=''> == Structural highli...)
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==Human SLK bound to a maleimide inhibitor==
==Human SLK bound to a maleimide inhibitor==
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<StructureSection load='6hvd' size='340' side='right' caption='[[6hvd]], [[Resolution|resolution]] 1.63&Aring;' scene=''>
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<StructureSection load='6hvd' size='340' side='right'caption='[[6hvd]], [[Resolution|resolution]] 1.63&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6hvd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HVD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HVD FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6hvd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HVD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6HVD FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GUQ:3-(1,3-benzothiazol-2-ylamino)-4-(2-methoxyphenyl)pyrrole-2,5-dione'>GUQ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.63&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GUQ:3-(1,3-benzothiazol-2-ylamino)-4-(2-methoxyphenyl)pyrrole-2,5-dione'>GUQ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hvd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hvd OCA], [http://pdbe.org/6hvd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hvd RCSB], [http://www.ebi.ac.uk/pdbsum/6hvd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hvd ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6hvd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hvd OCA], [https://pdbe.org/6hvd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6hvd RCSB], [https://www.ebi.ac.uk/pdbsum/6hvd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6hvd ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SLK_HUMAN SLK_HUMAN]] Mediates apoptosis and actin stress fiber dissolution.
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[https://www.uniprot.org/uniprot/SLK_HUMAN SLK_HUMAN] Mediates apoptosis and actin stress fiber dissolution.
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C]]
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[[Category: Large Structures]]
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[[Category: Bailey, H J]]
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[[Category: Arrowsmith C]]
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[[Category: Berger, B T]]
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[[Category: Bailey HJ]]
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[[Category: Bountra, C]]
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[[Category: Berger BT]]
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[[Category: Burgess-Brown, N A]]
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[[Category: Bountra C]]
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[[Category: Delft, F von]]
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[[Category: Burgess-Brown NA]]
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[[Category: Edwards, A M]]
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[[Category: Edwards AM]]
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[[Category: Elkins, J M]]
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[[Category: Elkins JM]]
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[[Category: Knapp, S]]
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[[Category: Knapp S]]
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[[Category: Krojer, T]]
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[[Category: Krojer T]]
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[[Category: Pinkas, D]]
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[[Category: Pinkas D]]
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[[Category: Salah, E]]
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[[Category: Salah E]]
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[[Category: Savitsky, P A]]
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[[Category: Savitsky PA]]
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[[Category: Serafim, R A.M]]
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[[Category: Serafim RAM]]
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[[Category: Sorrell, F J]]
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[[Category: Sorrell FJ]]
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[[Category: Kinase]]
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[[Category: Von Delft F]]
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[[Category: Transferase]]
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Human SLK bound to a maleimide inhibitor

PDB ID 6hvd

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