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| | ==Methanococcus jannaschii TBP== | | ==Methanococcus jannaschii TBP== |
| - | <StructureSection load='2z8u' size='340' side='right' caption='[[2z8u]], [[Resolution|resolution]] 1.90Å' scene=''> | + | <StructureSection load='2z8u' size='340' side='right'caption='[[2z8u]], [[Resolution|resolution]] 1.90Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[2z8u]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Metja Metja]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z8U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Z8U FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[2z8u]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z8U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z8U FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">tbp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243232 METJA])</td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z8u OCA], [http://pdbe.org/2z8u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2z8u RCSB], [http://www.ebi.ac.uk/pdbsum/2z8u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2z8u ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z8u OCA], [https://pdbe.org/2z8u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z8u RCSB], [https://www.ebi.ac.uk/pdbsum/2z8u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z8u ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/TBP_METJA TBP_METJA]] General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation (By similarity). | + | [https://www.uniprot.org/uniprot/TBP_METJA TBP_METJA] General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation (By similarity). |
| | == Evolutionary Conservation == | | == Evolutionary Conservation == |
| | [[Image:Consurf_key_small.gif|200px|right]] | | [[Image:Consurf_key_small.gif|200px|right]] |
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| | ==See Also== | | ==See Also== |
| - | *[[TATA-Binding Protein|TATA-Binding Protein]] | + | *[[TATA-binding protein 3D structures|TATA-binding protein 3D structures]] |
| | == References == | | == References == |
| | <references/> | | <references/> |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Metja]] | + | [[Category: Large Structures]] |
| - | [[Category: Adachi, N]] | + | [[Category: Methanocaldococcus jannaschii]] |
| - | [[Category: Horikoshi, M]] | + | [[Category: Adachi N]] |
| - | [[Category: Senda, T]] | + | [[Category: Horikoshi M]] |
| - | [[Category: Dna-binding protein]] | + | [[Category: Senda T]] |
| - | [[Category: Transcription]]
| + | |
| - | [[Category: Transcription factor]]
| + | |
| - | [[Category: Transcription regulation]]
| + | |
| Structural highlights
Function
TBP_METJA General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation (By similarity).
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
As the archaeal transcription system consists of a eukaryotic-type transcription apparatus and bacterial-type regulatory transcription factors, analyses of the molecular interface between the transcription apparatus and regulatory transcription factors are critical to reveal the evolutionary change of the transcription system. TATA box-binding protein (TBP), the central components of the transcription apparatus are classified into three groups: eukaryotic, archaeal-I and archaeal-II TBPs. Thus, comparative functional analysis of these three groups of TBP is important for the study of the evolution of the transcription system. Here, we present the first crystal structure of an archaeal-II TBP from Methanococcus jannaschii. The highly conserved and group-specific conserved surfaces of TBP bind to DNA and TFIIB/TFB, respectively. The phylogenetic trees of TBP and TFIIB/TFB revealed that they evolved in a coupled manner. The diversified surface of TBP is negatively charged in the archaeal-II TBP, which is completely different from the case of eukaryotic and archaeal-I TBPs, which are positively charged and biphasic, respectively. This difference is responsible for the diversification of the regulatory functions of TBP during evolution.
Crystal structure of Methanococcus jannaschii TATA box-binding protein.,Adachi N, Senda M, Natsume R, Senda T, Horikoshi M Genes Cells. 2008 Nov;13(11):1127-40. PMID:19090808[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Adachi N, Senda M, Natsume R, Senda T, Horikoshi M. Crystal structure of Methanococcus jannaschii TATA box-binding protein. Genes Cells. 2008 Nov;13(11):1127-40. PMID:19090808 doi:10.1111/j.1365-2443.2008.01233.x
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