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5l93

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==An atomic model of HIV-1 CA-SP1 reveals structures regulating assembly and maturation==
==An atomic model of HIV-1 CA-SP1 reveals structures regulating assembly and maturation==
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<StructureSection load='5l93' size='340' side='right' caption='[[5l93]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
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<SX load='5l93' size='340' side='right' viewer='molstar' caption='[[5l93]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5l93]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Hiv-1 Hiv-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L93 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L93 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5l93]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_type_1_(NEW_YORK-5_ISOLATE) Human immunodeficiency virus type 1 (NEW YORK-5 ISOLATE)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L93 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5L93 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">gag ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11698 HIV-1])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l93 OCA], [http://pdbe.org/5l93 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l93 RCSB], [http://www.ebi.ac.uk/pdbsum/5l93 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l93 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5l93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l93 OCA], [https://pdbe.org/5l93 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5l93 RCSB], [https://www.ebi.ac.uk/pdbsum/5l93 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5l93 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GAG_HV1N5 GAG_HV1N5]] Matrix protein p17 targets Gag and Gag-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex. Implicated in the release from host cell mediated by Vpu. Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex. Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers. p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1 (By similarity).
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[https://www.uniprot.org/uniprot/GAG_HV1N5 GAG_HV1N5] Matrix protein p17 targets Gag and Gag-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex. Implicated in the release from host cell mediated by Vpu. Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex. Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers. p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1 (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5l93" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5l93" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
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</StructureSection>
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</SX>
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[[Category: Hiv-1]]
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[[Category: Large Structures]]
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[[Category: Arjen, J J]]
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[[Category: Arjen JJ]]
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[[Category: Briggs, J A.G]]
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[[Category: Briggs JAG]]
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[[Category: Hagen, W J.H]]
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[[Category: Hagen WJH]]
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[[Category: Kirkpatrick, J M]]
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[[Category: Kirkpatrick JM]]
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[[Category: Kraeusslich, H G]]
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[[Category: Kraeusslich H-G]]
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[[Category: Obr, M]]
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[[Category: Obr M]]
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[[Category: Sachse, C]]
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[[Category: Sachse C]]
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[[Category: Schur, F K.M]]
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[[Category: Schur FKM]]
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[[Category: Wan, W]]
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[[Category: Wan W]]
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[[Category: Hiv-1 capsid sp1]]
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[[Category: Viral protein]]
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Current revision

An atomic model of HIV-1 CA-SP1 reveals structures regulating assembly and maturation

5l93, resolution 3.90Å

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OCA

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