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5lzs

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{{Large structure}}
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==Structure of the mammalian ribosomal elongation complex with aminoacyl-tRNA, eEF1A, and didemnin B==
==Structure of the mammalian ribosomal elongation complex with aminoacyl-tRNA, eEF1A, and didemnin B==
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<StructureSection load='5lzs' size='340' side='right' caption='[[5lzs]], [[Resolution|resolution]] 3.31&Aring;' scene=''>
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<SX load='5lzs' size='340' side='right' viewer='molstar' caption='[[5lzs]], [[Resolution|resolution]] 3.31&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5lzs]] is a 86 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LZS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LZS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5lzs]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LZS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LZS FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7C4:(2~{S})-~{N}-[(2~{R})-1-[[(3~{S},6~{S},8~{S},12~{S},13~{R},16~{S},17~{R},20~{S},23~{S})-13-[(2~{S})-BUTAN-2-YL]-20-[(4-METHOXYPHENYL)METHYL]-6,17,21-TRIMETHYL-3-(2-METHYLPROPYL)-12-OXIDANYL-2,5,7,10,15,19,22-HEPTAKIS(OXIDANYLIDENE)-8-PROPAN-2-YL-9,18-DIOXA-1,4,14,21-TETRAZABICYCLO[21.3.0]HEXACOSAN-16-YL]AMINO]-4-METHYL-1-OXIDANYLIDENE-PENTAN-2-YL]-~{N}-METHYL-1-[(2~{S})-2-OXIDANYLPROPANOYL]PYRROLIDINE-2-CARBOXAMIDE'>7C4</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.31&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7C4:(2~{S})-~{N}-[(2~{R})-1-[[(3~{S},6~{S},8~{S},12~{S},13~{R},16~{S},17~{R},20~{S},23~{S})-13-[(2~{S})-BUTAN-2-YL]-20-[(4-METHOXYPHENYL)METHYL]-6,17,21-TRIMETHYL-3-(2-METHYLPROPYL)-12-OXIDANYL-2,5,7,10,15,19,22-HEPTAKIS(OXIDANYLIDENE)-8-PROPAN-2-YL-9,18-DIOXA-1,4,14,21-TETRAZABICYCLO[21.3.0]HEXACOSAN-16-YL]AMINO]-4-METHYL-1-OXIDANYLIDENE-PENTAN-2-YL]-~{N}-METHYL-1-[(2~{S})-2-OXIDANYLPROPANOYL]PYRROLIDINE-2-CARBOXAMIDE'>7C4</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lzs OCA], [http://pdbe.org/5lzs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lzs RCSB], [http://www.ebi.ac.uk/pdbsum/5lzs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lzs ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lzs OCA], [https://pdbe.org/5lzs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lzs RCSB], [https://www.ebi.ac.uk/pdbsum/5lzs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lzs ProSAT]</span></td></tr>
</table>
</table>
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{{Large structure}}
 
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/U3KPD5_RABIT U3KPD5_RABIT]] Binds to the 23S rRNA.[RuleBase:RU000576] [[http://www.uniprot.org/uniprot/G1SS70_RABIT G1SS70_RABIT]] May play a role during erythropoiesis through regulation of transcription factor DDIT3.[HAMAP-Rule:MF_03122] [[http://www.uniprot.org/uniprot/EF1A1_RABIT EF1A1_RABIT]] This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production (By similarity).
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[https://www.uniprot.org/uniprot/G1U7M4_RABIT G1U7M4_RABIT]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Receptor for activated protein kinase C 1|Receptor for activated protein kinase C 1]]
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*[[Elongation factor 3D structures|Elongation factor 3D structures]]
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*[[3D sructureseceptor for activated protein kinase C 1|3D sructureseceptor for activated protein kinase C 1]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
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</StructureSection>
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</SX>
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[[Category: Large Structures]]
[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
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[[Category: Brown, A]]
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[[Category: Brown A]]
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[[Category: Hegde, R S]]
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[[Category: Hegde RS]]
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[[Category: Murray, J]]
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[[Category: Murray J]]
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[[Category: Ramakrishnan, V]]
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[[Category: Ramakrishnan V]]
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[[Category: Shao, S]]
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[[Category: Shao S]]
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[[Category: Taunton, J]]
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[[Category: Taunton J]]
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[[Category: Elongation]]
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[[Category: Ribosome]]
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[[Category: Translation]]
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Current revision

Structure of the mammalian ribosomal elongation complex with aminoacyl-tRNA, eEF1A, and didemnin B

5lzs, resolution 3.31Å

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