2z0u

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==Crystal structure of C2 domain of KIBRA protein==
==Crystal structure of C2 domain of KIBRA protein==
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<StructureSection load='2z0u' size='340' side='right' caption='[[2z0u]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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<StructureSection load='2z0u' size='340' side='right'caption='[[2z0u]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2z0u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z0U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Z0U FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2z0u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z0U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z0U FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z0u OCA], [http://pdbe.org/2z0u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2z0u RCSB], [http://www.ebi.ac.uk/pdbsum/2z0u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2z0u ProSAT], [http://www.topsan.org/Proteins/RSGI/2z0u TOPSAN]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z0u OCA], [https://pdbe.org/2z0u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z0u RCSB], [https://www.ebi.ac.uk/pdbsum/2z0u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z0u ProSAT], [https://www.topsan.org/Proteins/RSGI/2z0u TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/KIBRA_HUMAN KIBRA_HUMAN]] Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ. Plays a role in cognition and memory performance.<ref>PMID:15081397</ref> <ref>PMID:16684779</ref> <ref>PMID:18190796</ref> <ref>PMID:18596123</ref> <ref>PMID:18672031</ref> <ref>PMID:20159598</ref> <ref>PMID:23778582</ref>
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[https://www.uniprot.org/uniprot/KIBRA_HUMAN KIBRA_HUMAN] Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ. Plays a role in cognition and memory performance.<ref>PMID:15081397</ref> <ref>PMID:16684779</ref> <ref>PMID:18190796</ref> <ref>PMID:18596123</ref> <ref>PMID:18672031</ref> <ref>PMID:20159598</ref> <ref>PMID:23778582</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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<jmolCheckbox>
<jmolCheckbox>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z0/2z0u_consurf.spt"</scriptWhenChecked>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z0/2z0u_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Kato-Murayama, M]]
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[[Category: Large Structures]]
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[[Category: Murayama, K]]
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[[Category: Kato-Murayama M]]
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[[Category: Structural genomic]]
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[[Category: Murayama K]]
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[[Category: Shirouzu, M]]
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[[Category: Shirouzu M]]
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[[Category: Terada, T]]
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[[Category: Terada T]]
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[[Category: Yokoyama, S]]
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[[Category: Yokoyama S]]
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[[Category: Alternative splicing]]
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[[Category: C2 domain]]
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[[Category: Coiled coil]]
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[[Category: Cytoplasm]]
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[[Category: Lipid binding protein]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Phosphorylation]]
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[[Category: Polymorphism]]
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[[Category: Rsgi]]
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Current revision

Crystal structure of C2 domain of KIBRA protein

PDB ID 2z0u

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