2yru

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==Solution structure of mouse Steroid receptor RNA activator 1 (SRA1) protein==
==Solution structure of mouse Steroid receptor RNA activator 1 (SRA1) protein==
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<StructureSection load='2yru' size='340' side='right' caption='[[2yru]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2yru' size='340' side='right'caption='[[2yru]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2yru]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YRU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YRU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2yru]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YRU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YRU FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Sra1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yru OCA], [http://pdbe.org/2yru PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yru RCSB], [http://www.ebi.ac.uk/pdbsum/2yru PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yru ProSAT], [http://www.topsan.org/Proteins/RSGI/2yru TOPSAN]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yru OCA], [https://pdbe.org/2yru PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yru RCSB], [https://www.ebi.ac.uk/pdbsum/2yru PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yru ProSAT], [https://www.topsan.org/Proteins/RSGI/2yru TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SRA1_MOUSE SRA1_MOUSE]] Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis (By similarity).[UniProtKB:Q9HD15]
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[https://www.uniprot.org/uniprot/SRA1_MOUSE SRA1_MOUSE] Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis (By similarity).[UniProtKB:Q9HD15]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2yru ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2yru ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
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==See Also==
 
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*[[NMR Ensembles of Models|NMR Ensembles of Models]]
 
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Kigawa, T]]
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[[Category: Mus musculus]]
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[[Category: Koshiba, S]]
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[[Category: Kigawa T]]
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[[Category: Nameki, N]]
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[[Category: Koshiba S]]
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[[Category: Structural genomic]]
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[[Category: Nameki N]]
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[[Category: Saito, K]]
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[[Category: Saito K]]
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[[Category: Yokoyama, S]]
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[[Category: Yokoyama S]]
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[[Category: Apoptosis]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Rsgi]]
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[[Category: Srap]]
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Current revision

Solution structure of mouse Steroid receptor RNA activator 1 (SRA1) protein

PDB ID 2yru

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