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2yrh
From Proteopedia
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==Solution structure of the C2H2-type zinc finger domain (699-729) from zinc finger protein 473== | ==Solution structure of the C2H2-type zinc finger domain (699-729) from zinc finger protein 473== | ||
| - | <StructureSection load='2yrh' size='340' side='right' caption='[[2yrh | + | <StructureSection load='2yrh' size='340' side='right'caption='[[2yrh]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2yrh]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2yrh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YRH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YRH FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yrh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yrh OCA], [https://pdbe.org/2yrh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yrh RCSB], [https://www.ebi.ac.uk/pdbsum/2yrh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yrh ProSAT], [https://www.topsan.org/Proteins/RSGI/2yrh TOPSAN]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/ZN473_HUMAN ZN473_HUMAN] Involved in histone 3'-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3'-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases.<ref>PMID:11782445</ref> <ref>PMID:16914750</ref> <ref>PMID:16714279</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Hayashi F]] |
| - | [[Category: | + | [[Category: Qin XR]] |
| - | [[Category: Yokoyama | + | [[Category: Yokoyama S]] |
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Current revision
Solution structure of the C2H2-type zinc finger domain (699-729) from zinc finger protein 473
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