2z4p

<StructureSection load='2z4p' size='340' side='right' caption='[[2z4p]], [[Resolution|resolution]] 1.95&Aring;' scene=''>

<table><tr><td colspan='2'>[[2z4p]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z4P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Z4P FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ILE:ISOLEUCINE'>ILE</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z4p OCA], [http://pdbe.org/2z4p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2z4p RCSB], [http://www.ebi.ac.uk/pdbsum/2z4p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2z4p ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

Feast/famine regulatory proteins (FFRPs) comprise the largest group of archaeal transcription factors. Crystal structures of an FFRP, DM1 from Pyrococcus, were determined in complex with isoleucine, which increases the association state of DM1 to form octamers, and with selenomethionine, which decreases it to maintain dimers under some conditions. Asp39 and Thr/Ser at 69-71 were identified as being important for interaction with the ligand main chain. By analyzing residues surrounding the ligand side chain, partner ligands were identified for various FFRPs from Pyrococcus, e.g., lysine facilitates homo-octamerization of FL11, and arginine facilitates hetero-octamerization of FL11 and DM1. Transcription of the fl11 gene and lysine synthesis are regulated by shifting the equilibrium between association states of FL11 and by shifting the equilibrium toward association with DM1, in response to amino acid availability. With FFRPs also appearing in eubacteria, the origin of such regulation can be traced back to the common ancestor of all extant organisms, serving as a prototype of transcription regulations, now highly diverged.

A structural code for discriminating between transcription signals revealed by the feast/famine regulatory protein DM1 in complex with ligands.,Okamura H, Yokoyama K, Koike H, Yamada M, Shimowasa A, Kabasawa M, Kawashima T, Suzuki M Structure. 2007 Oct;15(10):1325-38. PMID:17937921<ref>PMID:17937921</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 2z4p" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Pyrococcus horikoshii]]

[[Category: Koike, H]]

[[Category: Kudo, N]]

[[Category: Suzuki, M]]

[[Category: Yamada, M]]

[[Category: Transcriptional regulator]]