2rex

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[[Image:2rex.jpg|left|200px]]
 
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{{Structure
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==Crystal structure of the effector domain of PLXNB1 bound with Rnd1 GTPase==
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|PDB= 2rex |SIZE=350|CAPTION= <scene name='initialview01'>2rex</scene>, resolution 2.300&Aring;
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<StructureSection load='2rex' size='340' side='right'caption='[[2rex]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>
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<table><tr><td colspan='2'>[[2rex]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2REX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2REX FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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|GENE= PLXNB1, KIAA0407, PLXN5, SEP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), RND1, RHO6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rex OCA], [https://pdbe.org/2rex PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rex RCSB], [https://www.ebi.ac.uk/pdbsum/2rex PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rex ProSAT]</span></td></tr>
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|RELATEDENTRY=[[2cls|2CLS]], [[2r2o|2R2O]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rex OCA], [http://www.ebi.ac.uk/pdbsum/2rex PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2rex RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/PLXB1_HUMAN PLXB1_HUMAN] Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration.<ref>PMID:12198496</ref> <ref>PMID:12196628</ref> <ref>PMID:15210733</ref> <ref>PMID:19843518</ref> <ref>PMID:20877282</ref> <ref>PMID:21912513</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/re/2rex_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rex ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of the effector domain of PLXNB1 bound with Rnd1 GTPase'''
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==See Also==
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*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
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*[[Plexin 3D structures|Plexin 3D structures]]
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==About this Structure==
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== References ==
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2REX is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2REX OCA].
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith CH]]
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[[Category: Bochkarev, A.]]
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[[Category: Bochkarev A]]
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[[Category: Edwards, A M.]]
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[[Category: Edwards AM]]
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[[Category: Park, H.]]
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[[Category: Park H]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Shen L]]
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[[Category: Shen, L.]]
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[[Category: Sundstrom M]]
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[[Category: Sundstrom, M.]]
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[[Category: Tempel W]]
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[[Category: Tempel, W.]]
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[[Category: Tong Y]]
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[[Category: Tong, Y.]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J.]]
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[[Category: alternative splicing]]
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[[Category: coiled coil]]
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[[Category: complex]]
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[[Category: cytoplasm]]
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[[Category: cytoskeleton]]
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[[Category: effector domain]]
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[[Category: glycoprotein]]
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[[Category: gnp]]
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[[Category: gtp-binding]]
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[[Category: gtpase]]
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[[Category: lipoprotein]]
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[[Category: membrane]]
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[[Category: methylation]]
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[[Category: nucleotide-binding]]
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[[Category: phosphorylation]]
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[[Category: plexin]]
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[[Category: polymorphism]]
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[[Category: prenylation]]
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[[Category: receptor]]
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[[Category: secreted]]
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[[Category: sgc]]
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[[Category: signaling protein/lipoprotein complex]]
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[[Category: structural genomics consortium]]
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[[Category: transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:59:36 2008''
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Current revision

Crystal structure of the effector domain of PLXNB1 bound with Rnd1 GTPase

PDB ID 2rex

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