2yqk
From Proteopedia
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==Solution structure of the SANT domain in Arginine-glutamic acid dipeptide (RE) repeats== | ==Solution structure of the SANT domain in Arginine-glutamic acid dipeptide (RE) repeats== | ||
| - | <StructureSection load='2yqk' size='340' side='right' caption='[[2yqk | + | <StructureSection load='2yqk' size='340' side='right'caption='[[2yqk]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2yqk]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2yqk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YQK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YQK FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yqk OCA], [https://pdbe.org/2yqk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yqk RCSB], [https://www.ebi.ac.uk/pdbsum/2yqk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yqk ProSAT], [https://www.topsan.org/Proteins/RSGI/2yqk TOPSAN]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/RERE_HUMAN RERE_HUMAN] Note=A chromosomal aberration involving RERE is found in the neuroblastoma cell line NGP. Translocation t(1;15)(p36.2;q24). |
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/RERE_HUMAN RERE_HUMAN] Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death.<ref>PMID:11331249</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: He | + | [[Category: Large Structures]] |
| - | [[Category: Inoue | + | [[Category: He F]] |
| - | [[Category: Kadirvel | + | [[Category: Inoue M]] |
| - | [[Category: Kigawa | + | [[Category: Kadirvel S]] |
| - | [[Category: Muto | + | [[Category: Kigawa T]] |
| - | + | [[Category: Muto Y]] | |
| - | [[Category: Shirouzu | + | [[Category: Shirouzu M]] |
| - | [[Category: Tarada | + | [[Category: Tarada T]] |
| - | [[Category: Yokoyama | + | [[Category: Yokoyama S]] |
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Current revision
Solution structure of the SANT domain in Arginine-glutamic acid dipeptide (RE) repeats
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Categories: Homo sapiens | Large Structures | He F | Inoue M | Kadirvel S | Kigawa T | Muto Y | Shirouzu M | Tarada T | Yokoyama S
