Proteopedia:Featured SEL/1

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(Avian Influenza Neuraminidase)
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<tr><td>[[Image:Anim Avian Influenza Neuraminidase.gif]]</td></tr>
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<tr><td>'''Avian Influenza Neuraminidase'''</td></tr>
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<tr><td>''Eric Martz''</td></tr>
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Image:Anim Avian Influenza Neuraminidase.gif
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<tr><td>H5N1 bird flu has seemed a likely pandemic threat for decades, but the first new influenza virus to emerge as an imminent pandemic threat in the 21st century is H1N1 swine flu. The drug oseltamivir (Tamiflu®) inhibits flu neuraminidase, a component necessary for virus spread, in susceptible flu strains. Luckily H1N1 swine flu is susceptible (at least in early May, 2009). The development of oseltamivir was guided, in part, by crystallographically determined structures of flu neuraminidase. Neuraminidase is a homotetramer, shown with oseltamivir bound. Oseltamivir was designed to fit N2/N9 (neuraminidases from other strains of flu). Serendipitously, it also fits N1, doing so by pulling one side of the binding site against itself (induced fit).
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<tr><td><div class='scrolling'>'''Avian Influenza Neuraminidase'''<br>
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''Eric Martz''<br>
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The first new influenza virus to emerge as an imminent pandemic threat in the 21st century is H1N1 swine flu. The drug '''oseltamivir''' (Tamiflu®) inhibits flu neuraminidase, a component necessary for virus spread, in susceptible flu strains. The development of oseltamivir was guided, in part, by crystallographically determined structures of flu neuraminidase, which is a homotetramer, shown with oseltamivir bound. Oseltamivir was designed to fit N2/N9 (neuraminidases from other strains of flu). Serendipitously, it also fits N1 by induced fit.
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>>> [[Avian_Influenza_Neuraminidase%2C_Tamiflu_and_Relenza|Visit this page]] >>>
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[[Category:Featured in Selected Pages]]

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Avian Influenza Neuraminidase

Eric Martz
The first new influenza virus to emerge as an imminent pandemic threat in the 21st century is H1N1 swine flu. The drug oseltamivir (Tamiflu®) inhibits flu neuraminidase, a component necessary for virus spread, in susceptible flu strains. The development of oseltamivir was guided, in part, by crystallographically determined structures of flu neuraminidase, which is a homotetramer, shown with oseltamivir bound. Oseltamivir was designed to fit N2/N9 (neuraminidases from other strains of flu). Serendipitously, it also fits N1 by induced fit.

>>> Visit this page >>>

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Angel Herraez, Jaime Prilusky

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