Proteopedia:Featured JRN/0
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| + | Image:Anim_Journal-JBIC-2_Hydrophobic_interactions.gif|center | ||
| + | default [[Journal:JBIC:2]] | ||
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<tr><td><div class="scrolling">'''Structure of Anticancer Ruthenium Half-Sandwich Complex Bound to Glycogen Synthase Kinase 3ß'''<br> | <tr><td><div class="scrolling">'''Structure of Anticancer Ruthenium Half-Sandwich Complex Bound to Glycogen Synthase Kinase 3ß'''<br> | ||
| - | ''G | + | ''G Atilla-Gocumen, L Di Costanzo, E Meggers''. J Biol Inorg Chem. 2010 doi: [http://dx.doi.org/10.1007/s00775-010-0699-x 10.1007/s00775-010-0699-x] <br> |
| - | A crystal structure of an organometallic half-sandwich ruthenium complex bound to | + | A crystal structure of an organometallic half-sandwich ruthenium complex bound to glycogen synthase kinase 3ß (GSK-3ß) reveals that the inhibitor binds to the ATP binding site via an induced fit mechanism utilizing several hydrogen bonds and hydrophobic interactions. Importantly, the metal is not involved in any direct interaction with the protein kinase but fulfills a purely structural role. |
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| + | >>> [[Journal:JBIC:2|Visit this I3DC complement]] >>> | ||
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</table> | </table> | ||
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| + | [[Category:Featured in I3DC]] | ||
Current revision
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Structure of Anticancer Ruthenium Half-Sandwich Complex Bound to Glycogen Synthase Kinase 3ß
G Atilla-Gocumen, L Di Costanzo, E Meggers. J Biol Inorg Chem. 2010 doi: 10.1007/s00775-010-0699-x >>> Visit this I3DC complement >>> |
