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6hwm
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of Thermus thermophilus ClpP in complex with bortezomib== | |
| - | + | <StructureSection load='6hwm' size='340' side='right'caption='[[6hwm]], [[Resolution|resolution]] 2.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6hwm]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HWM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6HWM FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BO2:N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE'>BO2</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6hwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hwm OCA], [https://pdbe.org/6hwm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6hwm RCSB], [https://www.ebi.ac.uk/pdbsum/6hwm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6hwm ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CLPP_THET2 CLPP_THET2] Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.[HAMAP-Rule:MF_00444] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Thermus thermophilus]] | ||
| + | [[Category: Felix J]] | ||
| + | [[Category: Fraga H]] | ||
| + | [[Category: Morlot C]] | ||
| + | [[Category: Schanda P]] | ||
Current revision
Structure of Thermus thermophilus ClpP in complex with bortezomib
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