6hxf

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m (Protected "6hxf" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6hxf is ON HOLD
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==Human STK10 bound to a maleimide inhibitor==
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<StructureSection load='6hxf' size='340' side='right'caption='[[6hxf]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6hxf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HXF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6HXF FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.09&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=R70:3-(2-methoxyphenyl)-4-[[4-(phenylcarbonyl)phenyl]amino]pyrrole-2,5-dione'>R70</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6hxf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hxf OCA], [https://pdbe.org/6hxf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6hxf RCSB], [https://www.ebi.ac.uk/pdbsum/6hxf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6hxf ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/STK10_HUMAN STK10_HUMAN] The disease may be caused by mutations affecting the gene represented in this entry.<ref>PMID:16175573</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/STK10_HUMAN STK10_HUMAN] Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo.<ref>PMID:11903060</ref> <ref>PMID:12639966</ref> <ref>PMID:19255442</ref>
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Authors: Sorrell, F.J., Salah, E., Serafim, R.A.M., Savitsky, P.A., Krojer, T., Bailey, H.J., Pinkas, D., Burgess-Brown, N.A., von Delft, F., Knapp, S., Arrowsmith, C., Bountra, C., Edwards, A.M., Elkins, J.M.
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==See Also==
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*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
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Description: Human STK10 bound to a maleimide inhibitor
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Elkins, J.M]]
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__TOC__
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[[Category: Knapp, S]]
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</StructureSection>
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[[Category: Bailey, H.J]]
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[[Category: Homo sapiens]]
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[[Category: Edwards, A.M]]
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[[Category: Large Structures]]
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[[Category: Salah, E]]
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[[Category: Arrowsmith C]]
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[[Category: Burgess-Brown, N.A]]
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[[Category: Bailey HJ]]
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[[Category: Krojer, T]]
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[[Category: Bountra C]]
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[[Category: Pinkas, D]]
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[[Category: Burgess-Brown NA]]
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[[Category: Serafim, R.A.M]]
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[[Category: Edwards AM]]
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[[Category: Von Delft, F]]
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[[Category: Elkins JM]]
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[[Category: Bountra, C]]
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[[Category: Knapp S]]
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[[Category: Arrowsmith, C]]
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[[Category: Krojer T]]
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[[Category: Savitsky, P.A]]
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[[Category: Pinkas D]]
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[[Category: Sorrell, F.J]]
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[[Category: Salah E]]
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[[Category: Savitsky PA]]
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[[Category: Serafim RAM]]
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[[Category: Sorrell FJ]]
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[[Category: Von Delft F]]

Current revision

Human STK10 bound to a maleimide inhibitor

PDB ID 6hxf

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