6hxr
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Human PARP16 (ARTD15) IN COMPLEX WITH EB-47== | |
| + | <StructureSection load='6hxr' size='340' side='right'caption='[[6hxr]], [[Resolution|resolution]] 2.90Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6hxr]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HXR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6HXR FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UHB:2-[4-[(2S,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-BIS(OXIDANYL)OXOLAN-2-YL]CARBONYLPIPERAZIN-1-YL]-N-(1-OXIDANYLIDENE-2,3-DIHYDROISOINDOL-4-YL)ETHANAMIDE'>UHB</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6hxr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hxr OCA], [https://pdbe.org/6hxr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6hxr RCSB], [https://www.ebi.ac.uk/pdbsum/6hxr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6hxr ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PAR16_HUMAN PAR16_HUMAN] Mono-ADP-ribosyltransferase targeting the karyopherin KPNB1. Plays a role in unfolded protein response (UPR), by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors.<ref>PMID:23103912</ref> <ref>PMID:22701565</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Poly(ADP-ribose) polymerase 3D structures|Poly(ADP-ribose) polymerase 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: Karlberg | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Schuler | + | [[Category: Large Structures]] |
| + | [[Category: Karlberg T]] | ||
| + | [[Category: Pinto AF]] | ||
| + | [[Category: Schuler H]] | ||
| + | [[Category: Thorsell AG]] | ||
Current revision
Human PARP16 (ARTD15) IN COMPLEX WITH EB-47
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