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4mmj
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==crystal structure of YafQ from E.coli strain BL21(DE3)== | ==crystal structure of YafQ from E.coli strain BL21(DE3)== | ||
| - | <StructureSection load='4mmj' size='340' side='right' caption='[[4mmj]], [[Resolution|resolution]] 1.80Å' scene=''> | + | <StructureSection load='4mmj' size='340' side='right'caption='[[4mmj]], [[Resolution|resolution]] 1.80Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4mmj]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4mmj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_BL21(DE3) Escherichia coli BL21(DE3)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MMJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MMJ FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | <tr id=' | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mmj OCA], [https://pdbe.org/4mmj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mmj RCSB], [https://www.ebi.ac.uk/pdbsum/4mmj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mmj ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/YAFQ_ECOBD YAFQ_ECOBD] Toxic component of a type II toxin-antitoxin (TA) system (PubMed:24923448). A sequence-specific mRNA endoribonuclease that inhibits translation elongation and induces bacterial stasis (Probable). Cleavage occurs between the second and third residue of the Lys codon followed by a G or A (5'AAA(G/A)3'), is reading-frame dependent and occurs within the 5' end of most mRNAs (By similarity). Ribosome-binding confers the sequence specificity and reading frame-dependence (By similarity). The YafQ-DinJ heterotetramer binds the consensus sequence 5'-TTTGAGCTACA-3' in the dinJ promoter; DinJ also binds DNA but not as well as the YafQ-DinJ complex (PubMed:24923448).[UniProtKB:Q47149]<ref>PMID:24923448</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Dong | + | [[Category: Dong Y]] |
| - | [[Category: Gao | + | [[Category: Gao Z]] |
| - | [[Category: Liang | + | [[Category: Liang Y]] |
| - | [[Category: Liu | + | [[Category: Liu Q]] |
| - | + | ||
| - | + | ||
Current revision
crystal structure of YafQ from E.coli strain BL21(DE3)
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Categories: Large Structures | Dong Y | Gao Z | Liang Y | Liu Q
