2tmk

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[[Image:2tmk.jpg|left|200px]]
 
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{{Structure
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==YEAST THYMIDYLATE KINASE COMPLEXED WITH 3'-AZIDO-3'-DEOXYTHYMIDINE MONOPHOSPHATE (AZT-MP)==
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|PDB= 2tmk |SIZE=350|CAPTION= <scene name='initialview01'>2tmk</scene>, resolution 2.4&Aring;
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<StructureSection load='2tmk' size='340' side='right'caption='[[2tmk]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=ATM:3&#39;-AZIDO-3&#39;-DEOXYTHYMIDINE-5&#39;-MONOPHOSPHATE'>ATM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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<table><tr><td colspan='2'>[[2tmk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2TMK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2TMK FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/dTMP_kinase dTMP kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.9 2.7.4.9] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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|GENE= CDC8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATM:3-AZIDO-3-DEOXYTHYMIDINE-5-MONOPHOSPHATE'>ATM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2tmk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2tmk OCA], [https://pdbe.org/2tmk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2tmk RCSB], [https://www.ebi.ac.uk/pdbsum/2tmk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2tmk ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2tmk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2tmk OCA], [http://www.ebi.ac.uk/pdbsum/2tmk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2tmk RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/KTHY_YEAST KTHY_YEAST] Catalyzes the conversion of dTMP to dTDP.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tm/2tmk_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2tmk ConSurf].
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<div style="clear:both"></div>
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'''YEAST THYMIDYLATE KINASE COMPLEXED WITH 3'-AZIDO-3'-DEOXYTHYMIDINE MONOPHOSPHATE (AZT-MP)'''
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==See Also==
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*[[Thymidylate kinase 3D structures|Thymidylate kinase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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2TMK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2TMK OCA].
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[[Category: Large Structures]]
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==Reference==
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Structure of thymidylate kinase reveals the cause behind the limiting step in AZT activation., Lavie A, Vetter IR, Konrad M, Goody RS, Reinstein J, Schlichting I, Nat Struct Biol. 1997 Aug;4(8):601-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9253404 9253404]
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Single protein]]
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[[Category: Lavie A]]
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[[Category: dTMP kinase]]
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[[Category: Schlichting I]]
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[[Category: Lavie, A.]]
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[[Category: Schlichting, I.]]
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[[Category: azt]]
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[[Category: enzyme]]
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[[Category: kinase]]
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[[Category: thymidine activation pathway]]
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[[Category: transferase (phosphotransferase)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:03:59 2008''
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Current revision

YEAST THYMIDYLATE KINASE COMPLEXED WITH 3'-AZIDO-3'-DEOXYTHYMIDINE MONOPHOSPHATE (AZT-MP)

PDB ID 2tmk

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