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6hzy
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6hzy is ON HOLD Authors: Description: Category: Unreleased Structures) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of a bacterial fucosidase with inhibitor FucPUG== | |
| + | <StructureSection load='6hzy' size='340' side='right'caption='[[6hzy]], [[Resolution|resolution]] 1.70Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6hzy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacteroides_thetaiotaomicron_VPI-5482 Bacteroides thetaiotaomicron VPI-5482]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HZY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6HZY FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GYZ:[(~{Z})-[(3~{S},4~{R},5~{S},6~{S})-6-methyl-3,4,5-tris(oxidanyl)oxan-2-ylidene]amino]+~{N}-phenylcarbamate'>GYZ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6hzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hzy OCA], [https://pdbe.org/6hzy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6hzy RCSB], [https://www.ebi.ac.uk/pdbsum/6hzy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6hzy ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q8A3I4_BACTN Q8A3I4_BACTN] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The sugar fucose plays a myriad of roles in biological recognition. Enzymes hydrolyzing fucose from glycoconjugates, alpha-L-fucosidases, are important targets for inhibitor and probe development. Here we describe the synthesis and evaluation of novel alpha-L-fucosidase inhibitors, with X-ray crystallographic analysis using an alpha-L-fucosidase from Bacteroides thetaiotamicron helping to lay a foundation for future development of inhibitors for this important enzyme class. | ||
| - | + | Synthetic and crystallographic insight into exploiting sp2-hybridization in the development of alpha-L-fucosidase inhibitors.,Coyle T, Wu L, Debowski A, Davies G, Stubbs KA Chembiochem. 2019 Jan 21. doi: 10.1002/cbic.201800710. PMID:30663832<ref>PMID:30663832</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 6hzy" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bacteroides thetaiotaomicron VPI-5482]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Coyle T]] | ||
| + | [[Category: Davies GJ]] | ||
| + | [[Category: Debowski AW]] | ||
| + | [[Category: Stubbs KA]] | ||
| + | [[Category: Wu L]] | ||
Current revision
Crystal structure of a bacterial fucosidase with inhibitor FucPUG
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