6i06
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6i06 is ON HOLD until sometime in the future Authors: Mandelman, D., Haser, R., Aghajari, N. Description: Crystal structure of psychrophilic phosph...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of psychrophilic phosphoglycerate kinase from Pseudomonas TACII18== | |
| + | <StructureSection load='6i06' size='340' side='right'caption='[[6i06]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6i06]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas Pseudomonas]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I06 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6I06 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6i06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i06 OCA], [https://pdbe.org/6i06 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6i06 RCSB], [https://www.ebi.ac.uk/pdbsum/6i06 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6i06 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q9RBS3_9PSED Q9RBS3_9PSED] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Crystal structures of phosphoglycerate kinase (PGK) from the psychrophile Pseudomonas sp. TACII 18 have been determined at high resolution by X-ray crystallography methods and compared with mesophilic, thermophilic and hyperthermophilic counterparts. PGK is a two-domain enzyme undergoing large domain movements to catalyze the production of ATP from 1,3-biphosphoglycerate and ADP. Whereas the conformational dynamics sustaining the catalytic mechanism of this hinge-bending enzyme now seems rather clear, the determinants which underlie high catalytic efficiency at low temperatures of this psychrophilic PGK were unknown. The comparison of the three-dimensional structures shows that multiple (global and local) specific adaptations have been brought about by this enzyme. Together, these reside in an overall increased flexibility of the cold-adapted PGK thereby allowing a better accessibility to the active site, but also a potentially more disordered transition state of the psychrophilic enzyme, due to the destabilization of some catalytic residues. | ||
| - | + | Structural determinants increasing flexibility confer cold adaptation in psychrophilic phosphoglycerate kinase.,Mandelman D, Ballut L, Wolff DA, Feller G, Gerday C, Haser R, Aghajari N Extremophiles. 2019 May 30. pii: 10.1007/s00792-019-01102-x. doi:, 10.1007/s00792-019-01102-x. PMID:31147836<ref>PMID:31147836</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 6i06" style="background-color:#fffaf0;"></div> |
| - | [[Category: Haser | + | |
| - | [[Category: | + | ==See Also== |
| + | *[[Phosphoglycerate kinase 3D structures|Phosphoglycerate kinase 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Pseudomonas]] | ||
| + | [[Category: Aghajari N]] | ||
| + | [[Category: Haser R]] | ||
| + | [[Category: Mandelman D]] | ||
Current revision
Crystal structure of psychrophilic phosphoglycerate kinase from Pseudomonas TACII18
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