6muo
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==CENP-A nucleosome bound by two copies of CENP-C(CD) and one copy CENP-N(NT)== | |
| + | <SX load='6muo' size='340' side='right' viewer='molstar' caption='[[6muo]], [[Resolution|resolution]] 3.60Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6muo]] is a 13 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MUO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MUO FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.6Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6muo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6muo OCA], [https://pdbe.org/6muo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6muo RCSB], [https://www.ebi.ac.uk/pdbsum/6muo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6muo ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CENPA_HUMAN CENPA_HUMAN] Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro).<ref>PMID:20739937</ref> <ref>PMID:21478274</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Centromere protein 3D structure|Centromere protein 3D structure]] | |
| - | + | *[[Histone 3D structures|Histone 3D structures]] | |
| - | [[Category: | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </SX> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Allu PK]] | ||
| + | [[Category: Black BE]] | ||
Current revision
CENP-A nucleosome bound by two copies of CENP-C(CD) and one copy CENP-N(NT)
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