2uy1

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[[Image:2uy1.jpg|left|200px]]
 
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{{Structure
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==CRYSTAL STRUCTURE OF CSTF-77==
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|PDB= 2uy1 |SIZE=350|CAPTION= <scene name='initialview01'>2uy1</scene>, resolution 2.00&Aring;
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<StructureSection load='2uy1' size='340' side='right'caption='[[2uy1]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[2uy1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Encephalitozoon_cuniculi Encephalitozoon cuniculi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UY1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UY1 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uy1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uy1 OCA], [https://pdbe.org/2uy1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uy1 RCSB], [https://www.ebi.ac.uk/pdbsum/2uy1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uy1 ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uy1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uy1 OCA], [http://www.ebi.ac.uk/pdbsum/2uy1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2uy1 RCSB]</span>
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[https://www.uniprot.org/uniprot/Q8SWC5_ENCCU Q8SWC5_ENCCU]
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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'''CRYSTAL STRUCTURE OF CSTF-77'''
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uy/2uy1_consurf.spt"</scriptWhenChecked>
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==Overview==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2uy1 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
The cleavage stimulation factor (CstF) is essential for the first step of poly(A) tail formation at the 3' ends of mRNAs. This heterotrimeric complex is built around the 77-kDa protein bridging both CstF-64 and CstF-50 subunits. We have solved the crystal structure of the 77-kDa protein from Encephalitozoon cuniculi at a resolution of 2 A. The structure folds around 11 Half-a-TPR repeats defining two domains. The crystal structure reveals a tight homodimer exposing phylogenetically conserved areas for interaction with protein partners. Mapping experiments identify the C-terminal region of Rna14p, the yeast counterpart of CstF-77, as the docking domain for Rna15p, the yeast CstF-64 homologue.
The cleavage stimulation factor (CstF) is essential for the first step of poly(A) tail formation at the 3' ends of mRNAs. This heterotrimeric complex is built around the 77-kDa protein bridging both CstF-64 and CstF-50 subunits. We have solved the crystal structure of the 77-kDa protein from Encephalitozoon cuniculi at a resolution of 2 A. The structure folds around 11 Half-a-TPR repeats defining two domains. The crystal structure reveals a tight homodimer exposing phylogenetically conserved areas for interaction with protein partners. Mapping experiments identify the C-terminal region of Rna14p, the yeast counterpart of CstF-77, as the docking domain for Rna15p, the yeast CstF-64 homologue.
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==About this Structure==
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The structure of the CstF-77 homodimer provides insights into CstF assembly.,Legrand P, Pinaud N, Minvielle-Sebastia L, Fribourg S Nucleic Acids Res. 2007;35(13):4515-22. Epub 2007 Jun 21. PMID:17584787<ref>PMID:17584787</ref>
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2UY1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Encephalitozoon_cuniculi Encephalitozoon cuniculi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UY1 OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The structure of the CstF-77 homodimer provides insights into CstF assembly., Legrand P, Pinaud N, Minvielle-Sebastia L, Fribourg S, Nucleic Acids Res. 2007;35(13):4515-22. Epub 2007 Jun 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17584787 17584787]
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</div>
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<div class="pdbe-citations 2uy1" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Encephalitozoon cuniculi]]
[[Category: Encephalitozoon cuniculi]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Fribourg, S.]]
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[[Category: Fribourg S]]
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[[Category: Legrand, P.]]
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[[Category: Legrand P]]
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[[Category: Minvielle-Sebastia, L.]]
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[[Category: Minvielle-Sebastia L]]
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[[Category: Pinaud, N.]]
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[[Category: Pinaud N]]
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[[Category: rna-binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:06:07 2008''
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Current revision

CRYSTAL STRUCTURE OF CSTF-77

PDB ID 2uy1

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