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1gu2

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(New page: 200px<br /> <applet load="1gu2" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gu2, resolution 1.19&Aring;" /> '''CRYSTAL STRUCTURE O...)
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[[Image:1gu2.gif|left|200px]]<br />
 
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<applet load="1gu2" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1gu2, resolution 1.19&Aring;" />
 
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'''CRYSTAL STRUCTURE OF OXIDIZED CYTOCHROME C" FROM METHYLOPHILUS METHYLOTROPHUS'''<br />
 
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==Overview==
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==Crystal structure of oxidized cytochrome c'' from Methylophilus methylotrophus==
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The crystal structures of the oxidized and reduced forms of cytochrome c", from Methylophilus methylotrophus were solved from X-ray synchrotron data, to atomic resolution. The overall fold of the molecule in the two redox, states is very similar and is comparable to that of the oxygen-binding, protein from the purple phototrophic bacterium Rhodobacter sphaeroides., However, significant modifications occur near the haem group, in, particular the detachment from axial binding of His95 observed upon, reduction as well as the adoption of different conformations of some, protonatable residues that form a possible proton path from the haem, pocket to the protein surface. These changes are associated with the, previously well characterized redox-Bohr behaviour of this protein., Furthermore they ... [[http://ispc.weizmann.ac.il/pmbin/getpm?16341897 (full description)]]
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<StructureSection load='1gu2' size='340' side='right'caption='[[1gu2]], [[Resolution|resolution]] 1.19&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1gu2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methylophilus_methylotrophus_W3A1 Methylophilus methylotrophus W3A1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GU2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GU2 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.19&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEC:HEME+C'>HEC</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gu2 OCA], [https://pdbe.org/1gu2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gu2 RCSB], [https://www.ebi.ac.uk/pdbsum/1gu2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gu2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CYCA_METME CYCA_METME]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gu/1gu2_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gu2 ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1GU2 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Methylophilus_methylotrophus Methylophilus methylotrophus]] with HEC as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GU2 OCA]].
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*[[Cytochrome C 3D structures|Cytochrome C 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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Structural evidence for a proton transfer pathway coupled with haem reduction of cytochrome c" from Methylophilus methylotrophus., Enguita FJ, Pohl E, Turner DL, Santos H, Carrondo MA, J Biol Inorg Chem. 2006 Mar;11(2):189-96. Epub 2005 Dec 10. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16341897 16341897]
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[[Category: Large Structures]]
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[[Category: Methylophilus methylotrophus]]
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[[Category: Methylophilus methylotrophus W3A1]]
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[[Category: Single protein]]
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[[Category: Carrondo MA]]
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[[Category: Carrondo, M.A.]]
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[[Category: Enguita FJ]]
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[[Category: Enguita, F.J.]]
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[[Category: Pohl E]]
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[[Category: Pohl, E.]]
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[[Category: Rodrigues A]]
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[[Category: Rodrigues, A.]]
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[[Category: Santos H]]
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[[Category: Santos, H.]]
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[[Category: HEC]]
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[[Category: electron transport]]
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[[Category: oxidoreductase]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 17:35:17 2007''
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Current revision

Crystal structure of oxidized cytochrome c from Methylophilus methylotrophus

PDB ID 1gu2

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