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3bs9

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==X-ray structure of human TIA-1 RRM2==
==X-ray structure of human TIA-1 RRM2==
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<StructureSection load='3bs9' size='340' side='right' caption='[[3bs9]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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<StructureSection load='3bs9' size='340' side='right'caption='[[3bs9]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3bs9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BS9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BS9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3bs9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BS9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BS9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TIA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bs9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bs9 OCA], [http://pdbe.org/3bs9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3bs9 RCSB], [http://www.ebi.ac.uk/pdbsum/3bs9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3bs9 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bs9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bs9 OCA], [https://pdbe.org/3bs9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bs9 RCSB], [https://www.ebi.ac.uk/pdbsum/3bs9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bs9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TIA1_HUMAN TIA1_HUMAN]] Involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.
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[https://www.uniprot.org/uniprot/TIA1_HUMAN TIA1_HUMAN] Involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Kielkopf, C L]]
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[[Category: Large Structures]]
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[[Category: Kumar, A O]]
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[[Category: Kielkopf CL]]
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[[Category: Apoptosis]]
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[[Category: Kumar AO]]
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[[Category: Phosphoprotein]]
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[[Category: Rbd]]
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[[Category: Rna binding domain]]
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[[Category: Rna binding protein]]
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[[Category: Rna recognition motif]]
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[[Category: Rna splicing]]
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[[Category: Rna-binding]]
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[[Category: Rrm]]
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Current revision

X-ray structure of human TIA-1 RRM2

PDB ID 3bs9

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