3btj

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==crystal structure of QacR(E58Q) bound to dequalinium==
==crystal structure of QacR(E58Q) bound to dequalinium==
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<StructureSection load='3btj' size='340' side='right' caption='[[3btj]], [[Resolution|resolution]] 2.98&Aring;' scene=''>
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<StructureSection load='3btj' size='340' side='right'caption='[[3btj]], [[Resolution|resolution]] 2.98&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3btj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BTJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BTJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3btj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_Mu50 Staphylococcus aureus subsp. aureus Mu50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BTJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BTJ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DEQ:DEQUALINIUM'>DEQ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.98&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1jt6|1jt6]], [[3bt9|3bt9]], [[3btc|3btc]], [[3bti|3bti]], [[1rkw|1rkw]], [[1qvu|1qvu]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DEQ:DEQUALINIUM'>DEQ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">qacR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3btj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3btj OCA], [https://pdbe.org/3btj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3btj RCSB], [https://www.ebi.ac.uk/pdbsum/3btj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3btj ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3btj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3btj OCA], [http://pdbe.org/3btj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3btj RCSB], [http://www.ebi.ac.uk/pdbsum/3btj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3btj ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/QACR_STAAM QACR_STAAM]] Transcriptional repressor of qacA. Binds to IR1, an unusually long 28 bp operator, which is located downstream from the qacA promoter and overlaps its transcription start site. QacR is induced from its IR1 site by binding to one of many structurally dissimilar cationic lipophilic compounds, which are also substrates of QacA (By similarity).
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[https://www.uniprot.org/uniprot/QACR_STAAM QACR_STAAM] Transcriptional repressor of qacA. Binds to IR1, an unusually long 28 bp operator, which is located downstream from the qacA promoter and overlaps its transcription start site. QacR is induced from its IR1 site by binding to one of many structurally dissimilar cationic lipophilic compounds, which are also substrates of QacA (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</div>
</div>
<div class="pdbe-citations 3btj" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3btj" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Tetracycline repressor protein 3D structures|Tetracycline repressor protein 3D structures]]
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*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Staphylococcus aureus]]
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[[Category: Large Structures]]
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[[Category: Brennan, R G]]
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[[Category: Staphylococcus aureus subsp. aureus Mu50]]
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[[Category: Schumacher, M A]]
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[[Category: Brennan RG]]
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[[Category: Schuman, J T]]
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[[Category: Schumacher MA]]
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[[Category: Bivalent drug]]
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[[Category: Schuman JT]]
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[[Category: Dequalinium]]
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[[Category: Dna-binding]]
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[[Category: Multidrug binding]]
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[[Category: Plasmid]]
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[[Category: Qacr]]
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[[Category: Repressor]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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Current revision

crystal structure of QacR(E58Q) bound to dequalinium

PDB ID 3btj

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