Negative elongation factor
From Proteopedia
(Difference between revisions)
(New page: <StructureSection load='6gml' size='340' side='right' caption='Caption for this structure' scene=''> == Function == '''Negative elongation factor''' (NELF) induces RNA polymerase II pro...) |
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| - | + | <StructureSection load='5l3x' size='340' side='right' caption='Human NELF A (grey) complex with NELF C/D (green) and Cl- ion (green) (PDB code [[5l3x]])' scene=''> | |
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== Function == | == Function == | ||
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NELF has been implicated in various diseases ranging from neurological disorders to cancer<ref>PMID:19245807</ref>. | NELF has been implicated in various diseases ranging from neurological disorders to cancer<ref>PMID:19245807</ref>. | ||
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| - | == Structural highlights == | ||
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</StructureSection> | </StructureSection> | ||
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[[5l3x]] - hNELF A + NELF C/D - human<br /> | [[5l3x]] - hNELF A + NELF C/D - human<br /> | ||
[[2bz2]], [[1x5p]], [[2jx2]] - hNELF E RNA recognition motif - NMR<br /> | [[2bz2]], [[1x5p]], [[2jx2]] - hNELF E RNA recognition motif - NMR<br /> | ||
| - | [[6gml]] - NELF A + NELF B + NELF C + NELF D + NELF E + RNA polymerase II + transcription elongation factors SPT4-SPT5 + DNA + RNA | + | [[6gml]] - NELF A + NELF B + NELF C + NELF D + NELF E + RNA polymerase II + transcription elongation factors SPT4-SPT5 + DNA + RNA - pig - Cryo EM<br /> |
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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3D structures of negative elongation factor
Updated on 31-October-2018
5l3x - hNELF A + NELF C/D - human
2bz2, 1x5p, 2jx2 - hNELF E RNA recognition motif - NMR
6gml - NELF A + NELF B + NELF C + NELF D + NELF E + RNA polymerase II + transcription elongation factors SPT4-SPT5 + DNA + RNA - pig - Cryo EM
References
- ↑ Natarajan M, Schiralli Lester GM, Lee C, Missra A, Wasserman GA, Steffen M, Gilmour DS, Henderson AJ. Negative elongation factor (NELF) coordinates RNA polymerase II pausing, premature termination, and chromatin remodeling to regulate HIV transcription. J Biol Chem. 2013 Sep 6;288(36):25995-6003. doi: 10.1074/jbc.M113.496489. Epub, 2013 Jul 24. PMID:23884411 doi:http://dx.doi.org/10.1074/jbc.M113.496489
- ↑ Yung TM, Narita T, Komori T, Yamaguchi Y, Handa H. Cellular dynamics of the negative transcription elongation factor NELF. Exp Cell Res. 2009 Jun 10;315(10):1693-705. doi: 10.1016/j.yexcr.2009.02.013., Epub 2009 Feb 23. PMID:19245807 doi:http://dx.doi.org/10.1016/j.yexcr.2009.02.013
